The effects of intravenous administration of cholecystokinin on feeding behaviour and release of pituitary hormones in pigs are not mediated by serotonergic (5-HT3) receptors
| Autor: | R.F. Parrott, I.S. Ebenezer, M.L. Forsling |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Vasopressin Hydrocortisone Swine Neuropeptide Lypressin Serotonergic Ondansetron Cellular and Molecular Neuroscience Internal medicine medicine Animals Receptor 5-HT receptor Cholecystokinin Pharmacology Chemistry digestive oral and skin physiology Antagonist Feeding Behavior Pituitary Hormones Endocrinology Receptors Serotonin Injections Intravenous Female hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Neuropharmacology. 31(9) |
| ISSN: | 0028-3908 |
| Popis: | Two experiments were carried out using the serotonergic (5-HT 3 ) antagonist ondansetron (GR 38032F) to investigate whether the actions of peripherally-administered cholecystokinin octapeptide (CCK) in the prepubertal pig might involve 5-HT 3 receptors. In Experiment 1, it was shown that ondansetron (10 or 30 mg, i.v.) did not affect the initial feeding response and did not modify the behavioural inhibition induced by a subsequent injection of CCK (1.3 μg/kg, i.v.). In Experiment 2, it was demonstrated that the nauseogenic action of CCK, indicated by its stimulatory effect on release of vasopressin and Cortisol, was not markedly altered by ondansetron (30 mg, i.v.). These results suggest that 5-HT 3 receptors play a negligible part in mediating the behavioural and endocrine responses induced by bolus intravenous injections of CCK in this species. |
| Databáze: | OpenAIRE |
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