Galectin-3 Modulates Immune and Inflammatory Responses during Helminthic Infection: Impact of Galectin-3 Deficiency on the Functions of Dendritic Cells
| Autor: | Irma van Die, Thierry Jouault, Isabelle Tillie-Leblond, Laetitia Breuilh, Christelle Faveeuw, François Vanhoutte, Josette Fontaine, François Trottein, Monique Capron, Caroline M.W. van Stijn, Philippe Gosset |
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| Rok vydání: | 2007 |
| Předmět: |
Galectin 3
T-Lymphocytes Immunology Antibodies Protozoan Priming (immunology) Inflammation Spleen Biology Microbiology Immunoglobulin G Mice Immune system medicine Animals Mice Knockout Host Response and Inflammation B-Lymphocytes Granuloma Dendritic Cells Schistosoma mansoni Dendritic cell biology.organism_classification Acquired immune system Schistosomiasis mansoni Infectious Diseases medicine.anatomical_structure Liver biology.protein Cytokines Female Parasitology medicine.symptom |
| Zdroj: | Infection and Immunity. 75:5148-5157 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.02006-06 |
| Popis: | Galectin-3 (Gal-3) is a multifunctional β-galactoside-binding lectin that senses self-derived and microbial glycoconjugates. Although Gal-3 is important in immune reactions and host defense in some experimental models, the function of Gal-3 during helminthic diseases (e.g., schistosomiasis) is still elusive. We show that, compared to wild-typeSchistosoma mansoni-infected mice, infected Gal-3−/−mice have a reduced number of T and B lymphocytes in the spleen, develop reduced liver granulomas at 7 weeks (acute phase) and 14 weeks (chronic phase) postinfection, and mount a biased cellular and humoral Th1 response. In an attempt to understand this latter phenomenon, we studied the role of endogenous Gal-3 in dendritic cells (DCs), the most potent antigen-presenting cells, both in vitro and in vivo. Although Gal-3 deficiency in DCs does not impact their differentiation and maturation processes, it greatly influences the strength (but not the nature) of the adaptive immune response that they trigger, suggesting that Gal-3 deficiency in some other cell types may be important during murine schistosomiasis. As a whole, this study implies that Gal-3 is a modulator of the immune/inflammatory responses during helminthic infection and reveals for the first time that Gal-3 expression in DCs is pivotal to control the magnitude of T-lymphocyte priming. |
| Databáze: | OpenAIRE |
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