Apolipoprotein B and Non-High-Density Lipoprotein Cholesterol Are Better Risk Markers for Coronary Artery Disease than Low-Density Lipoprotein Cholesterol in Hypertriglyceridemic Metabolic Syndrome Patients
| Autor: | Nesrine Kalboussi, Nabila Ben Rejeb, Jihène Rejeb, Naoufel Nabli, Asma Omezzine, Ahmed Ben Abdelaziz, Essia Boughazala, Lamia Rebhi, Ali Bouslama, Imen Boumaiza |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Blood lipids Coronary Artery Disease Coronary Angiography Models Biological Coronary artery disease chemistry.chemical_compound Risk Factors Internal medicine Internal Medicine medicine Humans education Aged Apolipoproteins B Hypertriglyceridemia Metabolic Syndrome education.field_of_study biology Cholesterol business.industry Insulin Cholesterol HDL Osmolar Concentration Cholesterol LDL Middle Aged Prognosis medicine.disease Endocrinology chemistry biology.protein Female lipids (amino acids peptides and proteins) Metabolic syndrome business Biomarkers Lipoprotein |
| Zdroj: | Metabolic Syndrome and Related Disorders. 8:515-522 |
| ISSN: | 1557-8518 1540-4196 |
| DOI: | 10.1089/met.2010.0006 |
| Popis: | Metabolic syndrome is highly prevalent in the general population. Small dense low-density lipoprotein (sd-LDL) particles have been considered as a risk marker in metabolic syndrome diagnosis. Apolipoprotein B (ApoB) concentration reflects the number of LDL particles and is closely associated with atherosclerosis. The aim of this study was to compare the associations of ApoB, non-high-density lipoprotein cholesterol (NHDL-C), and low-density lipoprotein cholesterol (LDL-C) with metabolic syndrome and its relationship with significant coronary stenosis (SCS) in a Tunisian population.We enrolled 192 patients, who underwent coronary angiography. The body mass index, blood lipids, fasting glucose, insulin concentration, and blood pressure of every patient were measured. Metabolic syndrome was diagnosed according to the International Diabetes Federation criteria.The frequency of metabolic syndrome was 58.3%. The comparison of the lipidic parameters between subject with and without metabolic syndrome showed a significant increase in ApoB and NHDL-C but not in LDL-C. By considering triglyceride (TG) limits (TG ≤ 0.9 mmol/L and TG1.70 mmol/L), we noted no differences in ApoB, NHDL-C, and LDL-C between subjects with and without metabolic syndrome in triglyceridemia ≤0.9 mmol/L. In triglyceridemia1.70 mmol/L, a significant increase in ApoB and NHDL-C, but not in LDL-C, was noted. These results seem to consolidate the probability of increased sd-LDL in hypertriglyceridemic metabolic syndrome subjects. Indeed, in our study the odds ratio (OR) of SCS associated with metabolic syndrome is 3.81 (P = 0.007) in the studied population. This risk increases to 8.70 (P = 0.026) in hypertriglyceridemic subjects and seems to be associated with ApoB and NHDL-C (OR = 1.87, P = 0.038; OR = 1.26, P = 0.048).This study suggests that ApoB and NHDL-C seem to be more correlated to SCS in metabolic syndrome with hypertriglyceridemia than LDL-C. |
| Databáze: | OpenAIRE |
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