Influence between NO and CO in guinea pig stomach fundus
| Autor: | Boris Kadinov, Dimitar Itzev |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Contraction
010405 organic chemistry Chemistry Guinea pig stomach guinea-pig Pharmaceutical Science Pharmacy Anatomy heme oxygenase 030226 pharmacology & pharmacy 01 natural sciences 0104 chemical sciences smooth muscle 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Fundus (uterus) histochemistry medicine Pharmacology (medical) Contraction guinea-pig hemin heme oxygenase histochemistry smooth muscle hemin |
| Zdroj: | Pharmacia 67(3): 161-168 |
| ISSN: | 2603-557X 0428-0296 |
| Popis: | The interaction between carbon monoxide and nitric oxide and their role in modulation of stomach fundus excitability was studied. The presence and colocalization of heme oxygenase 1 (HO-1) and nitric oxide synthase (NOS) was verified in myentheric ganglia by immunohistochemistry. The role of inducible heme oxygenase isoenzyme was investigated after in vivo treatment of animals with CoCl2 (80 mg kg-1 b.w.) injected subcutaneously 24 hours before euthanasia. This treatment resulted in positive staining for the inducible isoform in stomach smooth muscle. |
| Databáze: | OpenAIRE |
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