The Eukaryotic Linear Motif resource: 2022 release
| Autor: | Rita Pancsa, Tamas Lazar, Jesús Alvarado-Valverde, Ramya Kraleti, Hugo Sámano-Sánchez, László Dobson, Melanie Käser, Sushama Michael, Anurag Nagpal, Nazanin Farahi, András Zeke, Mihkel Örd, Bálint Mészáros, Lucía B. Chemes, Manjeet Kumar, Toby J. Gibson, Norman E. Davey |
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| Přispěvatelé: | Department of Bio-engineering Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Integrins
AcademicSubjects/SCI00010 Computational biology Saccharomyces cerevisiae Biology Communicable Diseases 03 medical and health sciences Mice 0302 clinical medicine Motif (narrative) Cyclins Genetics Database Issue Animals Humans Short linear motif Protein Interaction Domains and Motifs Databases Protein Transport Vesicles 030304 developmental biology 0303 health sciences Binding Sites Cell Cycle Cell Membrane Molecular Sequence Annotation Actin cytoskeleton Eukaryotic Linear Motif resource Rats Actin Cytoskeleton Eukaryotic Cells Gene Expression Regulation Host-Pathogen Interactions Viruses 030217 neurology & neurosurgery Software Protein Binding Signal Transduction |
| Zdroj: | Nucleic Acids Research |
| Popis: | Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource remains an invaluable source of information for the study of motif-mediated protein-protein interactions. ELM provides a comprehensive, regularly updated and well-organised repository of manually curated, experimentally validated short linear motifs (SLiMs). An increasing number of SLiM-mediated interactions are discovered each year and keeping the resource up-to-date continues to be a great challenge. In the current update, 30 novel motif classes have been added and five existing classes have undergone major revisions. The update includes 411 new motif instances mostly focused on cell-cycle regulation, control of the actin cytoskeleton, membrane remodelling and vesicle trafficking pathways, liquid-liquid phase separation and integrin signalling. Many of the newly annotated motif-mediated interactions are targets of pathogenic motif mimicry by viral, bacterial or eukaryotic pathogens, providing invaluable insights into the molecular mechanisms underlying infectious diseases. The current ELM release includes 317 motif classes incorporating 3934 individual motif instances manually curated from 3867 scientific publications. ELM is available at: http://elm.eu.org. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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