The Eukaryotic Linear Motif resource: 2022 release

Autor: Rita Pancsa, Tamas Lazar, Jesús Alvarado-Valverde, Ramya Kraleti, Hugo Sámano-Sánchez, László Dobson, Melanie Käser, Sushama Michael, Anurag Nagpal, Nazanin Farahi, András Zeke, Mihkel Örd, Bálint Mészáros, Lucía B. Chemes, Manjeet Kumar, Toby J. Gibson, Norman E. Davey
Přispěvatelé: Department of Bio-engineering Sciences
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nucleic Acids Research
Popis: Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource remains an invaluable source of information for the study of motif-mediated protein-protein interactions. ELM provides a comprehensive, regularly updated and well-organised repository of manually curated, experimentally validated short linear motifs (SLiMs). An increasing number of SLiM-mediated interactions are discovered each year and keeping the resource up-to-date continues to be a great challenge. In the current update, 30 novel motif classes have been added and five existing classes have undergone major revisions. The update includes 411 new motif instances mostly focused on cell-cycle regulation, control of the actin cytoskeleton, membrane remodelling and vesicle trafficking pathways, liquid-liquid phase separation and integrin signalling. Many of the newly annotated motif-mediated interactions are targets of pathogenic motif mimicry by viral, bacterial or eukaryotic pathogens, providing invaluable insights into the molecular mechanisms underlying infectious diseases. The current ELM release includes 317 motif classes incorporating 3934 individual motif instances manually curated from 3867 scientific publications. ELM is available at: http://elm.eu.org.
Databáze: OpenAIRE