Fatal outbreak of human toxoplasmosis along the Maroni River: epidemiological, clinical, and parasitological aspects

Autor: Christian Peneau, Daniel Ajzenberg, Bernard Carme, Félix Djossou, Laurence Terzan, Benoit Cottrelle, Magalie Demar, Widya Punwasi, Dayanand Panchoe, Jean-Louis Daigre, Marie-Laure Dardé, Danielle Maubon, Nasser Valery, Christine Aznar
Přispěvatelé: Université de Limoges (UNILIM), Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC) (CNR Toxoplasmose-Toxoplasma BRC), CHU Limoges, Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM)
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Male
Pediatrics
MESH: Pregnancy Complications
Parasitic
Serology
Disease Outbreaks
MESH: Genotype
0302 clinical medicine
MESH: Pregnancy
MESH: Suriname
Pregnancy
Epidemiology
Medicine
MESH: Animals
MESH: Disease Outbreaks
0303 health sciences
Suriname
MESH: Middle Aged
biology
MESH: Toxoplasma
MESH: Infant
Newborn
Middle Aged
MESH: Infant
Congenital toxoplasmosis
3. Good health
Vaccination
Infectious Diseases
MESH: Toxoplasmosis
Female
Toxoplasma
Toxoplasmosis
Microbiology (medical)
Adult
medicine.medical_specialty
Genotype
030231 tropical medicine
03 medical and health sciences
Animals
Humans
[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
Fetal Death
MESH: Humans
030306 microbiology
business.industry
Infant
Newborn
Outbreak
Toxoplasma gondii
Infant
MESH: Adult
biology.organism_classification
medicine.disease
MESH: Male
Infectious disease (medical specialty)
Pregnancy Complications
Parasitic
Immunology
MESH: Fetal Death
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
business
MESH: Female
Zdroj: Clinical Infectious Diseases
Clinical Infectious Diseases, Oxford University Press (OUP), 2007, 45 (7), pp.e88-95. ⟨10.1086/521246⟩
ISSN: 1058-4838
1537-6591
DOI: 10.1086/521246⟩
Popis: International audience; BACKGROUND: Well-documented outbreaks of human toxoplasmosis infection are infrequently reported. Here, we describe a community outbreak of multivisceral toxoplasmosis that occurred in Patam, a Surinamese village near the French Guianan border. METHODS: From the end of December 2003 through the middle of January 2004, 5 adult patients in Patam, including 2 pregnant women, were initially hospitalized for multivisceral toxoplasmosis. A French-Surinamese epidemiological investigation was conducted in the village; inquiries and clinical examinations were performed, and blood and environmental samples were obtained. For all serologically confirmed cases of toxoplasmosis, molecular analysis and mouse inoculations were performed for diagnosis and genetic characterization of Toxoplasma gondii. RESULTS: The hospitalized patients, who did not have any immunodeficiencies, presented with an infectious disease with multivisceral involvement. Serological examination confirmed acute toxoplasmosis. One adult died, and a neonate and a fetus with congenital toxoplasmosis also died. During the investigation, 4 additional acute cases of toxoplasmosis were diagnosed among the 33 villagers. Only 3 inhabitants had serological evidence of previous T. gondii infection. In total, we reported 11 cases of toxoplasmosis: 8 multivisceral cases in immunocompetent adults, resulting in 1 death; 2 cases of lethal congenital toxoplasmosis in a neonate and a fetus; and 1 symptomatic case in a child. Molecular analysis demonstrated that identical isolates of only 1 atypical strain were responsible for at least 5 of the 11 cases of toxoplasmosis in the outbreak. No epidemiological sources could be linked to this severe community-wide outbreak of toxoplasmosis. CONCLUSION: This report is in agreement with the particular features of toxoplasmosis involving atypical strains that were recently described in French Guiana.
Databáze: OpenAIRE
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