A controlled study to investigate anti-diarrhoeal effect of the stem-bark fractions of Terminalia avicennioides in laboratory animal models
| Autor: | Ahmed Abubakar, B. B. Oyelowo, Kamar-deen T. Bello, Mohammed Mamman, Mohammed M. Suleiman |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Veterinary medicine medicine.drug_class Ethyl acetate Rabbit Gastro-intestinal transit time Jejunum Guinea pig 03 medical and health sciences chemistry.chemical_compound Antidiarrhoeal medicine Anti-diarrhoeal Terminalia avicennioides Castor oil Stem bark lcsh:Veterinary medicine General Veterinary Traditional medicine biology Chemistry Laboratory Animal Models biology.organism_classification 030104 developmental biology medicine.anatomical_structure lcsh:SF600-1100 medicine.drug |
| Zdroj: | International Journal of Veterinary Science and Medicine, Vol 5, Iss 1, Pp 14-22 (2017) |
| ISSN: | 2314-4599 |
| Popis: | Due to the shortcomings associated with modern synthetic antidiarrhoeal drugs, it is important to find newer, safer and cheaper antidiarrhoeal agents from natural sources. The study was conducted to evaluate the anti-diarrhoeal activity of the fractions of the stem-bark of Terminalia avicennioides in laboratory animal models. The effect of different concentrations (1.0 × 10−3, 2.0 × 10−3, 4.0 × 10−3 and 8.0 × 10−3 mg/mL) of the aqueous methanol (AMF), ethyl acetate (EAF) and hexane (HXF) fractions of T. avicennioides were tested against spontaneous and acetylcholine-induced contractions of rabbit jejunum as well as on histamine-induced contraction of guinea pig ileum. Similarly, the effects of the AMF on gastro-intestinal transit time, castor oil-induced diarrhoea and castor oil-induced enteropooling were evaluated. The AMF, EAF and HXF at concentrations of 1.0 × 10−3, 2.0 × 10−3, 4.0 × 10−3 and 8.0 × 10−3 mg/mL attenuated the contractile effects of both the spontaneous and acetylcholine-induced contractions of rabbit jejunum and that of histamine-induced contraction of guinea pig ileum in a concentration-dependent manner. The AMF at doses of 200, 300 and 500 mg/kg produced significant (p |
| Databáze: | OpenAIRE |
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