The Potential Role of GnRH Agonists and Antagonists in Inducing Thyroid Physiopathological Changes during IVF
| Autor: | Carlo Alviggi, Roberta Venturella, Donato D'Antona, Mario Plebani, F. Esposito, Amerigo Vitagliano, Giovanni Battista Nardelli, Michele Gangemi, Michela Quaranta, Marco Noventa, Salvatore Gizzo, Alessandra Andrisani |
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| Přispěvatelé: | Gizzo, Salvatore, Noventa, Marco, Quaranta, Michela, Vitagliano, Amerigo, Esposito, Federica, Andrisani, Alessandra, Venturella, Roberta, Alviggi, Carlo, Plebani, Mario, Gangemi, Michele, Nardelli, Giovanni Battista, D'Antona, Donato |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty endocrine system diseases IVF outcome medicine.medical_treatment thyroid-stimulating hormone Thyroid Gland Thyrotropin 030209 endocrinology & metabolism Fertilization in Vitro controlled ovarian stimulation Cohort Studies Gonadotropin-Releasing Hormone 03 medical and health sciences Hormone Antagonists 0302 clinical medicine GnRH antagonist pregnancy rate thyroid autoimmunity thyroid function Obstetrics and Gynecology Thyroid-stimulating hormone Pregnancy Internal medicine Humans Medicine Triptorelin Pamoate 030219 obstetrics & reproductive medicine business.industry Thyroid Pregnancy Outcome Autoantibody Anti-thyroid autoantibodies Pregnancy rate Endocrinology medicine.anatomical_structure Female Ovulation induction Thyroid function business Infertility Female hormones hormone substitutes and hormone antagonists Hormone |
| Popis: | We conducted an observational cohort study to evaluate whether drugs used for hypothalamic inhibition may impact thyroid function of infertile women scheduled for fresh nondonor in vitro fertilization/intracytoplasmic sperm injection treatment. We considered eligible for inclusion in the study only women with normal thyroid function (serum thyroid-stimulating hormone [TSH] range: 0.2-4.0 mIU/L, serum thyroxin values: 9-22 pmol/L) and negative personal history for previous thyroid disorders. According to which protocols were implemented to gain hypothalamic inhibition, patients were assigned to group A (70 women treated by long gonadotropin-releasing hormone [GnRH] agonist protocol) or to group B (86 women treated by flexible GnRH antagonist protocol). Before initiating controlled ovarian stimulation (COS), both groups were further stratified into 4 subgroups: A1 (46 of the 70 women) and B1 (61 of the 86 women) in women with a baseline TSH value |
| Databáze: | OpenAIRE |
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