miR-144 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting E2F3
| Autor: | Hanjun Li, Yilin Hu, Tingjia Cao, Dandan Ma, Xun Cai |
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| Rok vydání: | 2014 |
| Předmět: |
Carcinoma
Hepatocellular Blotting Western Apoptosis Biology Real-Time Polymerase Chain Reaction Metastasis Cell Movement microRNA medicine Carcinoma Tumor Cells Cultured Humans RNA Messenger E2F neoplasms Transcription factor Cell Proliferation Cell growth Reverse Transcriptase Polymerase Chain Reaction Liver Neoplasms General Medicine medicine.disease Flow Cytometry digestive system diseases Gene Expression Regulation Neoplastic MicroRNAs Liver E2F3 Transcription Factor Hepatocellular carcinoma Cancer research |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 35(11) |
| ISSN: | 1423-0380 |
| Popis: | MicroRNAs (miRNAs) play essential roles in the progression of hepatocellular carcinoma (HCC). miR-144 acts as a tumor suppressor in some malignancies, while its role in HCC is unclear. Here, we found that miR-144 was significantly decreased in HCC tissues and cell lines. Forced overexpression of miR-144 remarkably reduced cell proliferation, increased apoptosis, and suppressed migration and invasion of HCC cells. E2F transcription factor 3 (E2F3) was identified as a target of miR-144 in HCC cells. Moreover, E2F3 overexpression partially attenuated the tumor suppressive effects of miR-144, and the expression of E2F3 was negatively correlated with miR-144 level in HCC tissues. Our data suggest that miR-144 might suppress the growth and motility of HCC cells partially by targeting E2F3. |
| Databáze: | OpenAIRE |
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