Thyroid tumor-initiating cells: Increasing evidence and opportunities for anticancer therapy (Review)
| Autor: | Jing Cui, Jian-Kui Han, Gao Yongju, Xinyu Wu, Bo Li |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
cancer stem cells
Cancer Research Tics Antineoplastic Agents Biology tumor-initiating cells cellular origin Side population Cancer stem cell mental disorders Biomarkers Tumor medicine Animals Humans Molecular Targeted Therapy Thyroid Neoplasms anticancer therapy Thyroid cancer Cell Proliferation Thyroid Cancer Articles General Medicine Aldehyde Dehydrogenase Cell cycle medicine.disease Molecular medicine Hyaluronan Receptors medicine.anatomical_structure Oncology Immunology Neoplastic Stem Cells Cancer research Signal Transduction |
| Zdroj: | Oncology Reports |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2014.2978 |
| Popis: | Accumulating evidence supports the notion that thyroid cancer is initiated by tumor-initiating cells (TICs) (commonly known as cancer stem cells), which are thought to play a crucial role in malignant progression, therapeutic resistance and recurrence. Thyroid TICs have been isolated and identified using specific biomarkers (such as CD133), the side population, sphere formation and aldehyde dehydrogenase activity assays. Although their characteristics remain largely unknown, TICs provide an attractive cellular mechanism to explain therapeutic refractoriness. Efforts are currently being directed toward the identification of therapeutic strategies that could target these cells. The present review discusses the cellular origins of TICs and the main approaches used to isolate and identify thyroid TICs, with a focus on the remaining challenges and opportunities for anticancer therapy. |
| Databáze: | OpenAIRE |
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