Etintidine-theophylline interaction study in humans
| Autor: | Robert Abels, Phillip T. Leese, Howard S. Weintraub, Barbara Marinan, Shiew-Mei Huang, Thomas B. Marriott |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Cmax Administration Oral Pharmaceutical Science Pharmacology Random Allocation Double-Blind Method Theophylline Pharmacokinetics Oral administration Bronchodilator Internal medicine medicine Humans Drug Interactions Pharmacology (medical) Cimetidine Chromatography High Pressure Liquid business.industry Imidazoles General Medicine Elixir Crossover study Endocrinology Histamine H2 Antagonists business medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 8:561-569 |
| ISSN: | 1099-081X 0142-2782 |
| DOI: | 10.1002/bdd.2510080607 |
| Popis: | Etintidine HCl is a potent H2-blocker. The effect of clinical doses of etintidine on the disposition of theophylline was investigated in 10 male volunteers. This was a double-blind, two-way crossover study. Each subject received etintidine (400 mg) or placebo twice a day with meals for 4 days on two occasions (separated by 4 days). On each occasion, the subjects were fasted overnight on Day 3 and were given an oral dose of theophylline elixir (5 mg/kg) 30 min following the administration of the morning dose of etintidine or placebo on Day 4. Blood samples were collected prior to and up to 24 h following the administration of theophylline. Plasma theophylline levels were analysed by HPLC. Theophylline was rapidly absorbed following oral administration of the theophylline elixir to both the placebo and etintidine treatment groups. Comparison of the pharmacokinetic parameters of theophylline between the etintidine and the placebo groups indicates that while etintidine did not significantly (p greater than 0.05) affect the apparent Cmax (11.1 vs 10.0 micrograms ml-1) and Tmax (1.7 vs 1.4 h) values of theophylline, etintidine significantly reduced the oral clearance (0.0200 vs 0.0564 l kg-1 h-1, p = 0.000006) and prolonged the elimination half-life (16.8 vs 6.0 h) of theophylline. The data indicate that etintidine, like cimetidine, extended the elimination of theophylline in humans. |
| Databáze: | OpenAIRE |
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