Podoplanin as Key Player of Tumor Progression and Lymph Vessel Proliferation in Ovarian Cancer
| Autor: | Ioan Sas, Raluca Amalia Ceaușu, Laurențiu Pirtea, Aurica Elisabeta Moatar, Ionut Marcel Cobec, Marius Raica, Anca Maria Cimpean |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty government.form_of_government Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Ovarian carcinoma Biomarkers Tumor medicine Humans Lymphangiogenesis Lymphatic Vessels Ovarian Neoplasms Membrane Glycoproteins business.industry General Medicine medicine.disease Lymphatic Endothelium Ki-67 Antigen 030104 developmental biology Lymphatic system Podoplanin Tumor progression Lymphatic Metastasis 030220 oncology & carcinogenesis government Cancer research Female business Ovarian cancer |
| Zdroj: | Anticancer Research. 36:5265-5272 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.11097 |
| Popis: | BACKGROUND/AIM Podoplanin plays a key role in tumor progression and metastasis. We evaluated lymphatics proliferation rate and podoplanin expression in tumor cells of ovarian carcinoma. MATERIALS AND METHODS Seventy-five paraffin-embedded specimens of ovarian cancer were immunohistochemically assessed in order to quantify peritumoral (LMVDP) and intratumoral (LMVDT) lymphatic microvessel density of proliferating lymphatics and for podoplanin variability in tumor cells. RESULTS AND CONCLUSION LMVDT correlated with proliferating tumor vessels located in the peritumoral area (p=0.024) and with the number of mature vessels located in the intratumoral area (p |
| Databáze: | OpenAIRE |
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