P53 and PCNA is positively correlated with HPV infection in laryngeal epitheliopapillomatous lesions in patiets with different ethnic backgrounds in Xinjiang
| Autor: | Zhao-Lun Chen, Hua Zhang, Ju Xiong, Jie Sun, Yan Zhen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Pathology China Epidemiology Malignancy medicine.disease_cause Gastroenterology Polymerase Chain Reaction law.invention Malignant transformation Immunoenzyme Techniques law Internal medicine Proliferating Cell Nuclear Antigen Biopsy medicine Humans Laryngeal Neoplasms Papillomaviridae Polymerase chain reaction Neoplasm Staging biology medicine.diagnostic_test Papilloma Papillomavirus Infections Public Health Environmental and Occupational Health HPV infection Middle Aged medicine.disease Prognosis Proliferating cell nuclear antigen Tumor Virus Infections Oncology DNA Viral biology.protein Coinfection Carcinoma Squamous Cell Female Tumor Suppressor Protein p53 Carcinogenesis |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 13(11) |
| ISSN: | 2476-762X |
| Popis: | Objective: To explore the correlation of human papillomavious (HPV) infection with expression of p53 and proliferating cell nuclear antigen (PCNA) in patients with different ethnicity in Xinjiang, China. Methods: 166 biopsy specimens from 83 laryngeal squamous cell carcinomas (LSCC), 63 laryngeal papillomas (LP), and 20 laryngeal inflammatory polyps (LIP) were included in this study. HPV infection was determined by polymerase chain reaction (PCR) using specific types of HPV primers. Expression of p53 and PCNA was assessed using immunohistostaining. Results: The frequency of HPV 6/11 was higher in LP (33.3%) than in LSCC (9.6%) (P |
| Databáze: | OpenAIRE |
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