Age-Related Changes in Tissue and Plasma Zinc Levels: Modulation by Exogenously Administered Melatonin

Autor:	Güler Öztürk, K. Gonca Akbulut, Lale Afrasyap
Přispěvatelé:	Maltepe Üniversitesi
Rok vydání:	2008
Předmět:	Male Aging medicine.medical_specialty Injections Subcutaneous chemistry.chemical_element Spleen Zinc Kidney Antioxidants Melatonin Subcutaneous injection Pineal gland Arts and Humanities (miscellaneous) hemic and lymphatic diseases Internal medicine medicine Animals Rats Wistar Pancreas neoplasms General Psychology Symporters Chemistry Micronutrient Small intestine Rats Endocrinology medicine.anatomical_structure Geriatrics and Gerontology medicine.drug
Zdroj:	Experimental Aging Research. 34:453-462
ISSN:	1096-4657 0361-073X 1872-6755
DOI:	10.1080/03610730802271922
Popis:	WOS: 000258688600009 PubMed ID: 18726755 Melatonin (MEL) is synthesized mainly in the pineal gland and derived from 5-hydroxytryptophan (5-HTP). Zinc (Zn) is one of the most important trace elements in the body. Zn and MEL levels are changed with aging. The aim of this study was to investigate the age-related changes of tissue and plasma Zn levels and effect of MEL administration on these parameters. Male wistar rats received for 3 weeks subcutaneous injection of MEL (10mg/kg). Kidney and pancreas Zn levels in old rats were significantly lower than middle-aged group. Spleen, small intestine, and plasma Zn levels were not different in middle-aged and old rats. On the other hand, MEL treatment increased Zn levels of small intestine and plasma in middle-aged rats. However, kidney, spleen, and pancreas Zn levels were unaffected by MEL treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33ebaf25f0a79438ba9dfb0788d7a59 https://doi.org/10.1080/03610730802271922 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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