Search of anti-allodynic compounds from Plantaginis Semen, a crude drug ingredient of Kampo formula 'Goshajinkigan'
| Autor: | Tsugunobu Andoh, Yue-Wei Ge, Huanhuan Yu, Shiho Hanazawa, Zhiyan Hou, Yanjing Bai, Miki Maesaka, Kazufumi Toume, Katsuko Komatsu, Mitsuru Kato |
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| Rok vydání: | 2019 |
| Předmět: |
Peripheral neuropathy
Kampo medicine.medical_treatment Intraperitoneal injection Plantaginis Semen Crude drug Pharmacology Allodynia 01 natural sciences chemistry.chemical_compound Ingredient Goshajinkigan Oral administration medicine Iridoids Aucubin Original Paper 010405 organic chemistry business.industry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Paclitaxel chemistry Molecular Medicine Plantago asiatica medicine.symptom business |
| Zdroj: | Journal of Natural Medicines |
| ISSN: | 1861-0293 1340-3443 |
| Popis: | Chemotherapy-induced peripheral neuropathy (CIPN) is one of the dose-limiting side effects of cancer chemotherapy. Although the control of CIPN is important, it is difficult to manage with currently available therapeutic drugs. Therefore, there is a need for novel therapeutic agents for treating CIPN. Goshajinkigan (GJG) is a Kampo formula composed of ten crude drugs. While GJG has been used for the treatment of CIPN, the active constituents of GJG and their underlying mechanisms of pharmacological effects are still unknown. Our previous study revealed that repetitive oral administration of the water extract of Plantaginis Semen, a crude drug ingredient of GJG, inhibited the mechanical allodynia induced by an intraperitoneal injection of paclitaxel in mice. To elucidate the active compounds of Plantaginis Semen, activity-guided separation of the water extract of Plantaginis Semen was performed. From the active fraction, four iridoids (1–4) were identified. Repetitive oral administration of aucubin (1) at 100 or 30 mg/kg and 100 mg/kg of the fraction crude 3 [primarily comprised of pedicularis-lactone (3)], showed anti-allodynic activity, suggesting 1 and 3 could be some of the active compounds responsible for the anti-allodynic property of Plantaginis Semen and GJG. Our study establishes that oral administration of 1 has potent anti-allodynic effect in addition to the activity of intraperitoneally administered 1 reported previously. Identification of active anti-allodynic compounds found in Kampo formulations will support the development of novel therapies for the management of CIPN in cancer patients. Electronic supplementary material The online version of this article (10.1007/s11418-019-01327-2) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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