No Effect of an Automated Bolus Calculator in Pediatric Patients with Type 1 Diabetes on Multiple Daily Injections: The Expert Kids Study
| Autor: | Jesse Vanbesien, Carmen Yoldi, Kurt Kristensen, Sara Van Aken, Raquel Corripio, Jacobo Perez Sanchez, Kristina Casteels, Marta Ramon-Krauel, Koen Vanbrabant, Eva Vandoorne, Jesper Johannesen, Magda Bontinck, Jens Madsen, Irune Goicoechea, Anne Marie Hertz, Kristian Casteels, Amparo Gonzalez-Vergaz, Steffen Fieuws, Lene Kolle Jorgensen, Roque Cardona Hernandez, Carine Devisscher |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Adolescent type 1 diabetes Endocrinology Diabetes and Metabolism CHILDREN METABOLIC-CONTROL THERAPY Injections law.invention Endocrinology & Metabolism Endocrinology Bolus (medicine) PEOPLE law GLYCEMIC CONTROL Diabetes mellitus ADOLESCENTS Humans Hypoglycemic Agents Insulin Medicine Drug Dosage Calculations Child Pediatric Glycated Hemoglobin COMPLICATIONS Type 1 diabetes Science & Technology Cross-Over Studies business.industry Blood Glucose Self-Monitoring Automated bolus calculator Multiple daily injections medicine.disease Crossover study Medical Laboratory Technology Diabetes Mellitus Type 1 Treatment Outcome Calculator Anesthesia Quality of Life Female business Life Sciences & Biomedicine |
| Zdroj: | Madsen, J O B, Casteels, K, Fieuws, S, Kristensen, K, Vanbrabant, K, Ramon-Krauel, M & Johannesen, J 2019, ' No Effect of an Automated Bolus Calculator in Pediatric Patients with Type 1 Diabetes on Multiple Daily Injections : The Expert Kids Study ', Diabetes Technology and Therapeutics, vol. 21, no. 6, pp. 322-328 . https://doi.org/10.1089/dia.2019.0064 |
| ISSN: | 1557-8593 1520-9156 |
| DOI: | 10.1089/dia.2019.0064 |
| Popis: | Background: This multicenter crossover study investigated the potential beneficial effect of an automated bolus calculator (ABC) in children and adolescents with type 1 diabetes (T1D) treated with multiple daily injections (MDI). Methods: Participants were randomized to either begin or end with a 5 months intervention versus their regular treatment regimen (control), separated by a 2 months washout period. During the intervention participants were carefully instructed to use the ABC (Accu-Check Aviva Expert) versus manual insulin calculations during the control period. Participants between 8 and 18 years of age with T1D were recruited from clinics in Denmark, Belgium, and Spain. Inclusion criteria included T1D for >1 year, a minimum of 3 months MDI treatment before inclusion, and HbA1c of 7.5%-11% (57-97 mmol/mol). Improvement in HbA1c was the main outcome, and improved quality of life (QoL) and glucose variability (time spent in target glucose) were secondary outcomes. Results: A total of 65 patients with a mean age of 13.25 years and a mean HbA1c of 8.25% (66.7 mmol/mol) were included. Midway evaluation after 2 months of intervention showed no significant difference from the standard care (0.297, 95% confidence interval [CI]: -0.645 to 0.054; P = 0.10). The difference remained insignificant after the 5 months of intervention (-0.143 [95% CI: -0.558 to 0.272; P = 0.51]). Using the ABC did not change the time spent in target glucose range, nor did it change the QoL. Conclusions: Our study did not demonstrate beneficial additive effects of an ABC in children and adolescents with T1D treated with MDI neither in HbA1c, nor in any other endpoint investigated. ispartof: DIABETES TECHNOLOGY & THERAPEUTICS vol:21 issue:6 pages:322-328 ispartof: location:United States status: published |
| Databáze: | OpenAIRE |
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