Intramolecular DNA Coiling Mediated by a Metallo-Supramolecular Cylinder

Autor:	Alison Rodger, Isabelle Meistermann, Erlend Moldrheim, Christian J. Isaac, Michael J. Hannon, María J. Prieto, Karen J. Sanders, Einar Sletten, Virtudes Moreno
Rok vydání:	2001
Předmět:	inorganic chemicals Atomic force microscopy Supramolecular chemistry Nanotechnology General Chemistry General Medicine Linear dichroism Catalysis chemistry.chemical_compound Crystallography chemistry Intramolecular force Cylinder Groove (engineering) DNA Minor groove
Zdroj:	Angewandte Chemie. 113:903-908
ISSN:	1521-3757 0044-8249
DOI:	10.1002/1521-3757(20010302)113:5<903::aid-ange903>3.0.co;2-o
Popis:	In the groove! A tetracationic supramolecular cylinder, [Fe2 L3 ]4+ (L=C25 H20 N4 ), with a triple-helical architecture is just the right size to fit into the major groove of DNA and too big to fit into the minor groove. NMR spectroscopic data confirm that the cylinder binds in the major groove. Linear dichroism shows that very low loadings of [Fe2 L3 ]4+ have a dramatic bending effect on the DNA and atomic force microscopy images show that this is an intramolecular effect resulting in coils of DNA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d339240e1fc9058ef397386c80c24c62 https://doi.org/10.1002/1521-3757(20010302)113:5<903::aid-ange903>3.0.co Zobrazit plný text záznamu Plný text