Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex

Autor:	Nour Abou Nader, Gustavo Zamberlam, Alexandre Boyer
Rok vydání:	2022
Předmět:	Mice Knockout Mammals Organic Chemistry Mice Transgenic General Medicine Catalysis Computer Science Applications Inorganic Chemistry Mice Adrenal Cortex Hormones Adrenal Cortex Animals Steroids Physical and Theoretical Chemistry Molecular Biology Spectroscopy
Zdroj:	International Journal of Molecular Sciences. 23:14388
ISSN:	1422-0067
DOI:	10.3390/ijms232214388
Popis:	The cortex of the adrenal gland is organized into concentric zones that produce distinct steroid hormones essential for body homeostasis in mammals. Mechanisms leading to the development, zonation and maintenance of the adrenal cortex are complex and have been studied since the 1800s. However, the advent of genetic manipulation and transgenic mouse models over the past 30 years has revolutionized our understanding of these mechanisms. This review lists and details the distinct Cre recombinase mouse strains available to study the adrenal cortex, and the remarkable progress total and conditional knockout mouse models have enabled us to make in our understanding of the molecular mechanisms regulating the development and maintenance of the adrenal cortex.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3354f49f425a8c2ec837925943e30c1 https://doi.org/10.3390/ijms232214388 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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