Biomarkers of vitamin B-12 status in NHANES: a roundtable summary
| Autor: | Regan L Bailey, Alison Tedstone, Lawrence C. Brody, Mary Frances Picciano, Jesse F. Gregory, L Randy Curtin, Ebba Nexo, Christopher T. Sempos, Barry Shane, Sheena Blackmore, Patrick J. Stover, John H. Eckfeldt, Jay L. Bock, Clifford L. Johnson, James L. Mills, Sally P. Stabler, Ralph Carmel, Ralph Green, Anne M. Molloy, Paul F. Jacques, Elizabeth A Yetley, Susan J. Thorpe, Christine M. Pfeiffer, Ramon Durazo-Arvizu, Andrew N. Hoofnagle, Paul M. Coates, Tsunenobu Tamura, Joseph M. Massaro, David A Lacher, Donald W. Jacobsen, Jeanne I. Rader, Karen W. Phinney, Jacob Selhub |
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| Rok vydání: | 2011 |
| Předmět: |
Vitamin
medicine.medical_specialty National Health and Nutrition Examination Survey Anemia Population Methylmalonic acid Medicine (miscellaneous) Cobalamin chemistry.chemical_compound Internal medicine Environmental health medicine Humans Vitamin B12 education Homocysteine education.field_of_study Nutrition and Dietetics business.industry Vitamin B 12 Deficiency Nutrition Surveys medicine.disease Vitamin B 12 B vitamins Endocrinology chemistry Public Health Cognition Disorders NHANES Monitoring of Biomarkers of Folate and Vitamin B-12 Status: a Roundtable Review business Biomarkers Methylmalonic Acid |
| Zdroj: | The American Journal of Clinical Nutrition Yetley, E A, Bailey, R L, Sempos, C, Coates, P M, Picciano, M F, Pfeiffer, C M, Phinney, K W, Blackmore, S, Bock, J L, Brody, L C, Carmel, R, Curtin, L R, Lacher, D A, Johnson, C L, Durazo-Arvizu, R A, Eckfeldt, J H, Green, R, Gregory III, J F, Hoofnagle, A N, Jacobsen, D W, Jacques, P F, Selhub, J, Molloy, A M, Massaro, J, Mills, J L, Nexo, E, Rader, J I, Shane, B, Stabler, S, Stover, P, Tamura, T, Tedstone, A & Thorpe, S J 2011, ' Biomarkers of vitamin B-12 status in NHANES : A roundtable summary ', American Journal of Clinical Nutrition, vol. 94, no. 1, pp. 313-21 . https://doi.org/10.3945/ajcn.111.013243 |
| ISSN: | 0002-9165 |
| DOI: | 10.3945/ajcn.111.013243 |
| Popis: | A roundtable to discuss the measurement of vitamin B-12 (cobalamin) status biomarkers in NHANES took place in July 2010. NHANES stopped measuring vitamin B-12 - related biomarkers after 2006. The roundtable reviewed 3 biomarkers of vitamin B-12 status used in past NHANES - serum vitamin B-12, methylmalonic acid (MMA), and total homocysteine (tHcy) - and discussed the potential utility of measuring holotranscobalamin (holoTC) for future NHANES. Theroundtable focused on public health considerations and the quality of the measurement procedures and reference methods and materials that past NHANES used or that are available for future NHANES. Roundtable members supported reinstating vitamin B-12 status measures in NHANES. They noted evolving concerns and uncertainties regarding whether subclinical (mild, asymptomatic) vitamin B-12 deficiency is a public health concern. They identified the need for evidence from clinical trials to address causal relations between subclinical vitamin B-12 deficiency and adverse health outcomes as well as appropriate cutoffs for interpreting vitamin B-12 - related biomarkers. Theyagreed thatproblems with sensitivityandspecificity of individual biomarkers underscore the need for including at least one biomarker of circulating vitamin B-12 (serum vitamin B-12 or holoTC) and one functional biomarker (MMA or tHcy) in NHANES. The inclusion of both serum vitamin B-12 and plasma MMA, which have been associated with cognitive dysfunction and anemia in NHANES and in other population-based studies, was preferable to provide continuity with past NHANES. Reliable measurement procedures are available, and National Institute of Standards and Technology reference materials are available or in development for serum vitamin B-12 and MMA. |
| Databáze: | OpenAIRE |
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