Assessing the effect of natural selection in malaria parasites
| Autor: | Venkatachalam Udhayakumar, Ananias A Escalante, Altaf A. Lal, Ascanio Rojas, Omar E. Cornejo |
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| Rok vydání: | 2004 |
| Předmět: |
Genetic diversity
Natural selection Plasmodium falciparum Antigens Protozoan Biological evolution Vaccine antigen Biology medicine.disease Biological Evolution Host-Parasite Interactions Malaria Phenotype Infectious Diseases Malaria Vaccines Immunology medicine Animals Humans Parasitology Engineering ethics Selection Genetic Protozoal disease Selection (genetic algorithm) |
| Zdroj: | Trends in Parasitology. 20:388-395 |
| ISSN: | 1471-4922 |
| DOI: | 10.1016/j.pt.2004.06.002 |
| Popis: | There are few concepts that have been used across disciplines; one of them is natural selection. The impact that this process has on parasite genetic diversity is reviewed here by discussing examples on drug resistance and vaccine antigens. Emphasis is made on how mechanisms need to be addressed rather than associations, and how such investigations were out of reach of biomedical researchers only a decade ago. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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