Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac
| Autor: | Noureldien H. E. Darwish, Dhruba J. Bharali, Shaker A. Mousa, Thangirala Sudha, Kelly A. Keating, Paul J. Davis, Hung Yun Lin, Melis Debreli Coskun, Murat Yalcin |
|---|---|
| Přispěvatelé: | Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı., Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü., Yalçın, Murat, Coşkun, Melis Debreli, AAG-6956-2021, AAF-3992-2020 |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Cell viability
Science & technology - other topics Mouse medicine.medical_treatment Docetaxel Nude mouse 0302 clinical medicine Nanoparticle Breast cancer International Journal of Nanomedicine Drug Discovery Antineoplastic agents Original Research media_common Xenografts Analogs and derivatives Tetraiodothyroacetic acid Diamino tetraiodothyroacetic acid nanoparticle Co-delivery General Medicine Nanoencapsulation Nanomedicine Paclitaxel Antineoplastic agent Drug screening 030220 oncology & carcinogenesis Thyroid-hormone Human Drug Ex vivo study NDAT media_common.quotation_subject Cells Drug delivery system Biophysics Bioengineering Article Biomaterials 03 medical and health sciences Drug formulation Humans Animal model Animal experiment Pharmacology & pharmacy Animal Drug adsorption Tumor cell line medicine.disease Thyroxine 030104 developmental biology Cell line tumor Nanoscience & nanotechnology chemistry Cancer cell Nanoparticles tetraiodothy-roacetic acid Cisplatin 0301 basic medicine Drug uptake Unclassified drug Polylactic acid-polyglycolic acid copolymer Pharmaceutical Science Integrin Growth Cell survival Animal tissue chemistry.chemical_compound In-vitro In vivo study Tumor volume Pancreas cancer biology Lactic acid Particle size Drug delivery systems Chemistry Drug delivery Nanotetrac Dynamic light scattering Female Animal cell medicine.drug Receptor Xenograft model antitumor assays Pancreatic neoplasms Breast Neoplasms medicine Animals Doxorubicin Antineoplastic activity Chemotherapy Drug effects Photon correlation spectroscopy Organic Chemistry Cancer Polyglycolic acid biology.organism_classification Nonhuman Thyroid Hormones Nano-Diamino-Tetrac Drug efficacy Cancer research Mice nude Controlled study Activated protein-kinase |
| Zdroj: | International Journal of Nanomedicine |
| Popis: | Thangirala Sudha,1 Dhruba J Bharali,1 Murat Yalcin,1,2 Noureldien HE Darwish,1,3 Melis Debreli Coskun,1,4 Kelly A Keating,1 Hung-Yun Lin,5,6 Paul J Davis,1,7 Shaker A Mousa1 1The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, NY, USA; 2Department of Physiology, Veterinary Medicine Faculty, Uludag University, Gorukle, Bursa, Turkey; 3Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; 4Department of Biology, Faculty of Arts and Sciences, Uludag University, Gorukle, Bursa, Turkey; 5PhD Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, 6Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan; 7Department of Medicine, Albany Medical College, Albany, NY, USA Abstract: The tetraiodothyroacetic acid (tetrac) component of nano-diamino-tetrac (NDAT) is chemically bonded via a linker to a poly(lactic-co-glycolic acid) nanoparticle that can encapsulate anticancer drugs. Tetrac targets the plasma membrane of cancer cells at a receptor on the extracellular domain of integrin αvβ3. In this study, we evaluate the efficiency of NDAT delivery of paclitaxel and doxorubicin to, respectively, pancreatic and breast cancer orthotopic nude mouse xenografts. Intra-tumoral drug concentrations were 5-fold (paclitaxel; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|