The Serum Mac-2-binding Protein Glycosylation Isomer Dynamics in Acute Liver Injury

Autor: Hajime Ohta, Kenichi Harada, Shuichi Kaneko, Takuya Seike, Yoshiaki Shimizu, Masashi Unoura, Atsuhiro Kawashima, Takashi Kagaya, Tatsuo Kumai, Takuya Komura, Hitoshi Omura
Rok vydání: 2020
Předmět:
Adult
Liver Cirrhosis
Male
Receptors
N-Acetylglucosamine

medicine.medical_specialty
M2BPGi
Glycosylation
Mononucleosis
Bilirubin
acute liver injury
030204 cardiovascular system & hematology
Severity of Illness Index
Gastroenterology
Wisteria floribunda agglutinin-positive human Mac-2-binding protein
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Antigens
Neoplasm

Internal medicine
Internal Medicine
medicine
Humans
Retrospective Studies
Liver injury
Membrane Glycoproteins
biology
WFA+-M2BP
business.industry
Albumin
Alanine Transaminase
General Medicine
Middle Aged
Alkaline Phosphatase
medicine.disease
Wisteria floribunda
biology.organism_classification
Liver
chemistry
Etiology
Alkaline phosphatase
Original Article
Female
030211 gastroenterology & hepatology
Plant Lectins
business
Biomarkers
Zdroj: Internal Medicine
ISSN: 1349-7235
0918-2918
Popis: Objective We aimed to examine the dynamics of serum Wisteria floribunda agglutinin-positive human Mac-2-binding protein glycosylation isomer (M2BPGi) in patients with acute liver injury. Methods Serum M2BPGi levels at the time of the diagnosis (n=77) and normalization of the serum alanine aminotransferase (ALT) level (n=26) were examined retrospectively. The difference in the serum M2BPGi level according to the etiology, and the correlations with other laboratory parameters were evaluated. Results The serum M2BPGi level at the time of the diagnosis was increased in 59 of 77 patients [2.3 cutoff index (COI); range, 0.31-11.1 COI] and was significantly decreased at the time of serum ALT normalization (0.68 COI; range, 0.15-1.87 COI; p
Databáze: OpenAIRE