Plasma homocysteine is a predictor of alcohol withdrawal seizures
| Autor: | Johannes Kornhuber, S. Bleich, Detlef Degner, Borwin Bandelow, von Ahsen N, E. Rüther |
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| Rok vydání: | 2000 |
| Předmět: |
Agonist
Adult Male medicine.medical_specialty Homocysteine medicine.drug_class Homocystinuria 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Folic Acid Predictive Value of Tests Seizures Internal medicine Alcohol Withdrawal Seizures Convulsion medicine Humans Ethanol General Neuroscience Glutamate receptor Odds ratio Middle Aged medicine.disease Homocysteic acid 030227 psychiatry Substance Withdrawal Syndrome Endocrinology chemistry Female medicine.symptom Psychology 030217 neurology & neurosurgery Forecasting |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0959-4965 |
| Popis: | An adaptive consequence of prolonged ethanol consumption is a compensatory up-regulation of NMDA receptors in certain brain areas. Taking into account that homocysteine and its breakdown products (i.e. homocysteic acid) are putative neurotransmitters and agonists at the NMDA receptor, the aim of this study was to assess the influence of levels of homocysteine on alcohol withdrawal seizures. Six patients with chronic alcoholism who suffered from withdrawal seizures had significantly higher levels of homocysteine on admission (84.7 +/- 29.8 micromol/l) than patients (n = 26) who did not develop seizures (30.2 +/- 23.2 micromol/l; U = 8.0, p = 0.0007). Furthermore, seizure patients had significantly lower levels of folate and significantly higher blood alcohol concentrations. Using a logistic regression analysis, withdrawal seizures were best predicted by a high homocysteine level on admission (p < 0.01; odds ratio = 1.05). Homocysteine levels on admission may be a useful screening method to identify patients at risk for withdrawal seizures. |
| Databáze: | OpenAIRE |
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