Circulating androgens are associated with mood disturbances in young postmenopausal women

Autor:	Areti C. Spyropoulou, Ioannis Zervas, Eleni Armeni, Maria Creatsa, Irene Lambrinoudaki, A. A. Leonadrou, Areti Augoulea, S. Dendrinos, Andreas Alexandrou, Constantinos Panoulis, Demetrios Rizos, K. Koundi, G. Bouziou
Rok vydání:	2015
Předmět:	Adult medicine.medical_specialty media_common.quotation_subject Anger Anxiety Sex hormone-binding globulin Sex Hormone-Binding Globulin Internal medicine medicine Humans Depression (differential diagnoses) Aged media_common biology Dehydroepiandrosterone Sulfate Depression Mood Disorders Free androgen index business.industry Obstetrics and Gynecology General Medicine Middle Aged Anthropometry medicine.disease Aggression Postmenopause Cross-Sectional Studies Standard error Endocrinology Mood disorders Androgens biology.protein Female medicine.symptom business
Zdroj:	Climacteric. 18:205-213
ISSN:	1473-0804 1369-7137
DOI:	10.3109/13697137.2014.984674
Popis:	We aimed to evaluate the association between circulating androgens and the presence of psychological symptoms in a sample of healthy middle-aged women.Psychological and depressive symptoms were evaluated in a total of 207 postmenopausal women, using the Symptom Checklist-90-R (SCL-90R) and the Zung Depression Scale, respectively. We investigated the associations between the SCL-90R and Zung Scale scores, and anthropometric, lifestyle parameters, as well as serum levels of androgens.The free androgen index was positively associated with scores of depression (b-coefficient ± standard error (SE) = 0.2 ± 0.2, p = 0.040), anxiety (b-coefficient ± SE = 0.2 ± 0.2, p = 0.028), anger/aggressiveness (b-coefficient ± SE = 0.3 ± 0.2, p = 0.026), psychotism (b-coefficient ± SE = 0.3 ± 0.1, p = 0.013) as well as with the global index of the SCL-90R scale (b-coefficient ± SE = 0.2 ± 0.1, p = 0.036), while sex hormone binding globulin was negatively associated with depression (b-coefficient ± SE = -0.2 ± 0.0, p = 0.046) and psychotism (b-coefficient ± SE = -0.2 ± 0.0, p = 0.047). These associations were independent of vasomotor symptomatology, smoking and hormone therapy intake and were more pronounced in younger (≤ 5.5 years) compared to older postmenopausal women. Levels of dehydroepiandrosterone sulfate were positively associated with interpersonal sensitivity (b-coefficient ± SE = 0.3 ± 0.3, p = 0.042), psychotism (b-coefficient ± SE = 0.4 ± 0.2, p = 0.007) and the global index (b-coefficient ± SE = 0.3 ± 0.2, p = 0.040) in women5.5 years postmenopausal. No significant associations were observed between the Zung or Greene Scale scores and levels of androgens.Higher androgenicity was positively associated with symptoms of anxiety and depression in postmenopausal women. These associations were stronger in women closer to the menopausal transition, a finding which may suggest that menopause rather than aging may mediate the association of androgens with mood disorders.
Databáze:	OpenAIRE
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