Hydroxy-Selenomethionine Improves the Selenium Status and Helps to Maintain Broiler Performances under a High Stocking Density and Heat Stress Conditions through a Better Redox and Immune Response
| Autor: | Lv-Hui Sun, Mickael Briens, Ling Zhao, Zi-Jian Xu, Xiang-Hua Yan, Hua Sun, Michele De Marco |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Physiology
Clinical Biochemistry chemistry.chemical_element health status RM1-950 selenoprotein GPX4 Biochemistry Redox Article Jejunum heat stress chemistry.chemical_compound Immune system Animal science medicine Molecular Biology chemistry.chemical_classification hydroxy-selenomethionine Chemistry Broilers Broiler stocking density Cell Biology Malondialdehyde medicine.anatomical_structure Therapeutics. Pharmacology Selenoprotein Selenium |
| Zdroj: | Antioxidants Volume 10 Issue 10 Antioxidants, Vol 10, Iss 1542, p 1542 (2021) |
| ISSN: | 2076-3921 |
| DOI: | 10.3390/antiox10101542 |
| Popis: | This study has determined whether hydroxy-selenomethionine (OH-SeMet) exerts a better protective action on broilers against environmental stress than sodium selenite (SS) or seleno-yeast (SY). Day-old male Cobb 500 broilers (12 cages/diet, 9 broilers/cage) were fed a selenium (Se)-deficient diet (0.047 mg/kg) supplemented with SS, SY or OH-SeMet at 0.3 mg Se/kg under a high stocking density and heat stress condition for six weeks. OH-SeMet improved the FCR and Se concentration in the tissues than SS and SY. SY and OH-SeMet both reduced the serum cortisol, T3, IL-6, IgA, IgM and LPS, more than SS, while only OH-SeMet further increased IL-10 and IgG. SY and OH-SeMet improved the intestinal morphology and increased the T-AOC, TXRND, SELENON and OCCLUDIN activities but decreased CLAUDIN2 in the jejunum than SS, while OH-SeMet further improved these values than SY. SY and OH-SeMet both increased SELENOS and TXNRD2 in the muscles than SS, and OH-SeMet further raised T-AOC, GPX4, SELENOP, SELENOW and TXNRD1, and reduced malondialdehyde and protein carbonyl in the muscles than SS and SY. OH-SeMet showed a better ability to maintain the performance and the redox and immune status of broilers under a high stocking density and heat stress challenge than SS and SY. |
| Databáze: | OpenAIRE |
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