Early Complications With Preloaded Descemet Membrane Endothelial Keratoplasty Are Not Dependent on Optisol-GS Washout or Trypan Blue Restaining
| Autor: | Miles F. Greenwald, Winston Chamberlain, Christopher G. Stoeger, Afshan A. Nanji, Richard D. Stutzman, John L. Clements |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Graft failure genetic structures Descemet membrane Fuchs Endothelial Dystrophy Visual Acuity Complex Mixtures Article Culture Media Serum-Free Fibrin chemistry.chemical_compound Postoperative Complications Ophthalmology Humans Medicine Coloring Agents Aged Retrospective Studies biology business.industry Chondroitin Sulfates Endothelium Corneal Graft Survival Washout Dextrans Trypan Blue Corneal Endothelial Cell Loss Toxic anterior segment syndrome medicine.disease Tissue Donors eye diseases chemistry biology.protein Female Trypan blue sense organs Gentamicins Postoperative inflammation business Descemet Stripping Endothelial Keratoplasty Follow-Up Studies |
| Zdroj: | Cornea |
| ISSN: | 0277-3740 |
| Popis: | Purpose To describe the intraoperative and early postoperative complications using preloaded Descemet membrane endothelial keratoplasty (DMEK) grafts with intraocular injection of the graft in Optisol-GS and omission of trypan blue restaining. Methods This is a retrospective case series of 132 consecutive eyes with Fuchs endothelial dystrophy or endothelial failure who underwent DMEK using preloaded donor tissue prepared as previously described. The graft was not restained with trypan blue by the surgeon, and Optisol-GS was injected with the graft into the eye instead of being rinsed from the injector. Early postoperative complications (0-8 wk) including intraoperative fibrin formation, intraocular inflammation, elevated intraocular pressure, partial graft detachment requiring rebubble, and early graft failure were recorded. Results No eyes developed intraoperative fibrin formation or postoperative inflammation (such as toxic anterior segment syndrome) or elevated intraocular pressure. For eyes with Fuchs corneal dystrophy, our rebubble rate was 21% (22/106 eyes). Early graft failure was noted in 2% (3/132 eyes), which is similar to previous reports. Conclusions Our results suggest that injection of Optisol-GS into the anterior chamber during DMEK graft injection does not lead to increases in intraoperative or early postoperative complications. Trypan blue restaining is not necessary for intraoperative visualization. This simplification can reduce graft manipulation and save time and resources for this procedure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|