Impaired sense of smell and altered olfactory system in RAG-1−∕− immunodeficient mice
| Autor: | Ridhika Poojara, Yehuda Shoenfeld, Anna Cariboni, Fulvio D'Acquisto, Lorenza Rattazzi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Olfactory system
Physiology Olfaction Biology olfactory dysfunction lcsh:RC321-571 emotional behavior Immune system Atrophy main olfactory epithelium (MOE) Gene expression medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research immunosuppression General Neuroscience main and accessory olfactory system (MOS and AOS) 1702 Cognitive Science medicine.disease anxiety Phenotype medicine.anatomical_structure Knockout mouse 1109 Neurosciences Neuroscience Olfactory epithelium immunodeficiency |
| Zdroj: | Frontiers in Neuroscience, Vol 9 (2015) Frontiers in Neuroscience |
| ISSN: | 1662-453X |
| DOI: | 10.3389/fnins.2015.00318 |
| Popis: | Immune deficiencies are often associated with a number of physical manifestations including loss of sense of smell and an increased level of anxiety. We have previously shown that T and B cell-deficient recombinase activating gene (RAG-1)(-∕-) knockout mice have an increased level of anxiety-like behavior and altered gene expression involved in olfaction. In this study, we expanded these findings by testing the structure and functional development of the olfactory system in RAG-1 (-∕-) mice. Our results show that these mice have a reduced engagement in different types of odors and this phenotype is associated with disorganized architecture of glomerular tissue and atrophy of the main olfactory epithelium. Most intriguingly this defect manifests specifically in adult age and is not due to impairment in the patterning of the olfactory neuron staining at the embryo stage. Together these findings provide a formerly unreported biological evidence for an altered function of the olfactory system in RAG-1 (-∕-) mice. |
| Databáze: | OpenAIRE |
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