The effect of oral quercetin on UVB-induced tumor growth and local immunosuppression in SKH-1
| Autor: | H. van Loveren, A.P.J. Verlaan, E. Geerse, P. A. Steerenberg, H.B. Bueno-de-Mesquita, Y. Sontag, P.M. Dortant, H. van der Vliet, J. Garssen, Wim G. Goettsch |
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| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
Neoplasms Radiation-Induced Skin Neoplasms Ultraviolet Rays medicine.medical_treatment Administration Oral Mice Inbred Strains Spleen CD8-Positive T-Lymphocytes Biology Pharmacology Dermatitis Contact medicine.disease_cause Mice chemistry.chemical_compound Immune system Oral administration medicine Animals heterocyclic compounds skin and connective tissue diseases integumentary system Immunosuppression Hairless medicine.anatomical_structure Oncology chemistry Immunology Quercetin Lymph Carcinogenesis |
| Zdroj: | Cancer Letters. 114:187-189 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(97)04659-4 |
| Popis: | The effects of quercetin (4%) on UVB-induced carcinogenesis and immunosuppression were studied in hairless SKH-1 mice exposed daily to suberythemal UVB for 12/13 and 16/17 weeks. Macroscopic and microscopic examinations showed that quercetin did not affect the onset and growth of UVB-induced non-melanoma skin tumors. Quercetin prevented the UV-induced suppression of the contact hypersensitivity (CHS) and the reduction of the percentage of CD8-positive cells in spleen and lymph nodes. Other immunological parameters were not affected. Thus, the results indicate that oral intake of a high dose of quercetin does not prevent UVB-induced carcinogenesis, although it restores the skin-associated CHS response. |
| Databáze: | OpenAIRE |
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