Diminished Excretion of Bicarbonate from the Single Sweat Gland of Patients with Cystic Fibrosis of the Pancreas
| Autor: | E. Drack, PD Dr. D. Kaiser |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male medicine.medical_specialty Exocrine gland Cell Membrane Permeability Cystic Fibrosis Bicarbonate Clinical Biochemistry Biochemistry Cystic fibrosis Excretion chemistry.chemical_compound Body Water Sweat gland Internal medicine medicine Humans Child Sweat Chemistry Reabsorption Sodium Pancreatic Diseases Biological Transport Epithelial Cells General Medicine Hydrogen-Ion Concentration Water-Electrolyte Balance medicine.disease Sweat Glands Bicarbonates medicine.anatomical_structure Endocrinology Child Preschool Potassium Female Pancreas Microelectrodes Duct (anatomy) |
| Zdroj: | European Journal of Clinical Investigation. 4:261-265 |
| ISSN: | 1365-2362 0014-2972 |
| DOI: | 10.1111/j.1365-2362.1974.tb00402.x |
| Popis: | Using pH-microelectrodes the excretion of hydrogen-ions and bicarbonate in relation to flow rate was investigated in a single sweat gland of cystic fibrosis children. The results show decreased excretion of hydrogen-ions and an increased excretion of bicarbonate. Evidence is presented that due to reduced secretion of hydrogen-ions in the duct both the reabsorption of sodium and the secretion of potassium may be impaired. The possibility is discussed that reduced flux of hydrogen-ions may similarly be responsible for the excretory defect in the duct system of the pancreas. Reduced flux of protons across the luminal membrane of epithelial cells is proposed as a general feature of exocrine gland defects. It is then possible to describe both the cationic transport defect of the sweat gland duct and the anionic bicarbonate-secretory defect in one term. |
| Databáze: | OpenAIRE |
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