The predictive value of maternal serum AFP to PAPP-A or b-hCG ratios in spontaneous preterm birth
| Autor: | Çelik, Ebru, Melekoğlu, Rauf, Baygül, Arzu, Kalkan, Üzeyir, Şimşek, Yavuz |
|---|---|
| Přispěvatelé: | Tıp Fakültesi |
| Rok vydání: | 2022 |
| Předmět: |
Placenta
AFP Infant Newborn Obstetrics and Gynecology Maternal Biochemical Markers Preterm Birth Pregnancy Trimester First Pregnancy Humans Pregnancy-Associated Plasma Protein-A Premature Birth Chorionic Gonadotropin beta Subunit Human Female Prospective Studies alpha-Fetoproteins PAPP-A Β-Hcg Biomarkers |
| Zdroj: | Journal of Obstetrics and Gynaecology. 42:1956-1961 |
| ISSN: | 1364-6893 0144-3615 |
| DOI: | 10.1080/01443615.2022.2055452 |
| Popis: | The use of the second trimester alpha-fetoprotein (AFP) along with the first trimester pregnancy-associated plasma protein-A (PAPP-A) has been found to be useful in the estimation of unfavourable pregnancy outcome. Our aim in this study was to determine the relationship between maternal PAPP-A and b-hCG and AFP concentrations in spontaneous preterm birth (sPTB). This prospective cohort study included 372 singleton pregnancies with PAPP-A, b-hCG and AFP levels in the first trimester, which were converted to multiples of the median (MoM). The predictive ability of AFP-to-PAPP-A and AFP-to-b-hCG ratios for sPTB was evaluated. The risk for sPTB ≤34 weeks increased in women with AFP-to-PAPP-A ratio7 (OR 2.9, 95% CI 1.2-6.4). Women with AFP-to-b-hCG ratio0.6 had a 3.5-fold higher risk for sPTB ≤32 weeks. Increased maternal AFP-to-PAPP-A or AFP-to-b-hCG ratios in the first trimester may help to predict pregnant women at high risk for sPTB, and this may be beneficial in developing management plans.Impact Statement |
| Databáze: | OpenAIRE |
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