Dexmedetomidine Alleviates Postpartum Depressive Symptoms following Cesarean Section in Chinese Women: A Randomized Placebo-Controlled Study
| Autor: | Chao Fang, Dan-Yang Li, Chengxuan Quan, Sai-Ying Wang, Kai-Ming Duan, Shan-Shan Zhen, Shi-Chao Luo, He-Ya Yu, Jia-Hui Ma |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Sedation 030106 microbiology Placebo-controlled study 030204 cardiovascular system & hematology Sufentanil Depression Postpartum 03 medical and health sciences 0302 clinical medicine Double-Blind Method Pregnancy Outcome Assessment Health Care medicine Elective Cesarean Delivery Humans Pharmacology (medical) Sleep Hygiene Dexmedetomidine Psychiatric Status Rating Scales business.industry Cesarean Section Incidence Analgesics Non-Narcotic medicine.disease Edinburgh Postnatal Depression Scale Anesthesia Antenatal depression Analgesia Obstetrical Female medicine.symptom business medicine.drug |
| Zdroj: | PharmacotherapyReferences. 39(10) |
| ISSN: | 1875-9114 |
| Popis: | OBJECTIVES Few studies have investigated the prophylactic efficacy of dexmedetomidine (DEX) in postpartum depressive symptoms (PDS). A randomized double-blind placebo-controlled trial was conducted to investigate whether the administration of DEX, immediately after delivery and for patient-controlled intravenous analgesia (PCIA), can attenuate PDS. METHODS A total of 600 parturients scheduled for elective cesarean delivery under spinal anesthesia were randomly allocated into the control group (infusion with 0.9% normal saline after delivery and PCIA with sufentanil) and the DEX group (DEX infusion 0.5 μg/kg after delivery and PCIA with DEX plus sufentanil). The prevalence of postpartum depressive disorders was indicated by the Edinburgh Postnatal Depression Scale (EPDS). Postoperative analgesia, sedation, and sleep quality of parturients were also assessed. RESULTS Postpartum blues and PDS prevalence in the DEX, versus control, group were significantly lower (5.0% vs 14.1%, p |
| Databáze: | OpenAIRE |
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