Structure and Properties of Members of the hGH Family
| Autor: | Urban J. Lewis, Y. N. Sinha, Geoffrey P. Lewis |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Pituitary gland Endocrinology Diabetes and Metabolism Dimer Peptide Retina Structure-Activity Relationship chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Structure–activity relationship chemistry.chemical_classification Human Growth Hormone business.industry Human growth hormone Disulfide bond Genetic Variation medicine.disease Molecular Weight Exogenous insulin medicine.anatomical_structure Biochemistry chemistry Multigene Family Pituitary Gland business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrine Journal. 47:S1-S8 |
| ISSN: | 1348-4540 0918-8959 |
| Popis: | This review will summarize the properties of five variant forms of human growth hormone: a disulfide dimer, a glycosylated form, 20 kD-hGH, and two peptides made up of portions of 22 kD-hGH. The two pituitary peptides (hGH(1-43) and hGH(44-191)) have, respectively, insulin-potentiating and anti-insulin properties. Both have been detected in serum. The shorter peptide may prove to be useful in decreasing the amount of exogenous insulin required by diabetics. The larger, strongly anti-insulin peptide, may be involved in diabetic retinopathy. We believe that this peptide is the long sought after diabetogenic substance of the pituitary gland. |
| Databáze: | OpenAIRE |
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