Structure and Properties of Members of the hGH Family

Autor: Urban J. Lewis, Y. N. Sinha, Geoffrey P. Lewis
Rok vydání: 2000
Předmět:
Zdroj: Endocrine Journal. 47:S1-S8
ISSN: 1348-4540
0918-8959
Popis: This review will summarize the properties of five variant forms of human growth hormone: a disulfide dimer, a glycosylated form, 20 kD-hGH, and two peptides made up of portions of 22 kD-hGH. The two pituitary peptides (hGH(1-43) and hGH(44-191)) have, respectively, insulin-potentiating and anti-insulin properties. Both have been detected in serum. The shorter peptide may prove to be useful in decreasing the amount of exogenous insulin required by diabetics. The larger, strongly anti-insulin peptide, may be involved in diabetic retinopathy. We believe that this peptide is the long sought after diabetogenic substance of the pituitary gland.
Databáze: OpenAIRE