Effect of hypertriglyceridemia in dyslipidemia‐induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study

Autor: Yukiko Nonoyama, Mayumi Yamamoto, Shino Oba, Yukio Horikawa, Chisato Nagata, Daisuke Yabe, Jun Takeda, Gifu Diabetes Study Group
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Blood Glucose
Male
Endocrinology
Diabetes and Metabolism
030204 cardiovascular system & hematology
Impaired glucose tolerance
chemistry.chemical_compound
Eating
0302 clinical medicine
Japan
Medicine
Hypertriglyceridemia
General Medicine
Articles
Middle Aged
Lipoproteins
LDL
Clinical Science and Care
lipids (amino acids
peptides
and proteins)
Original Article
Female
Lipoproteins
HDL
Adult
medicine.medical_specialty
030209 endocrinology & metabolism
Diet Surveys
Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
Insulin resistance
Sex Factors
Internal medicine
Diabetes mellitus
Sex differences
Glucose Intolerance
Internal Medicine
Humans
Obesity
Risk factor
Aged
Dyslipidemias
Glycated Hemoglobin
Triglyceride
business.industry
medicine.disease
RC648-665
Diet
Endocrinology
Cross-Sectional Studies
chemistry
Glycated hemoglobin
Insulin Resistance
business
Dyslipidemia
Zdroj: Journal of Diabetes Investigation
Journal of Diabetes Investigation, Vol 12, Iss 5, Pp 771-780 (2021)
ISSN: 2040-1124
2040-1116
Popis: Aims/Introduction The mechanisms underlying hypertriglyceridemia‐induced impaired glucose tolerance in Japanese individuals remain unclear. We aimed to evaluate the effect of hypertriglyceridemia on glucose metabolism in comparison with that of increased low‐density lipoprotein or decreased high‐density lipoprotein levels and to elucidate the sex differences in hypertriglyceridemia‐related dietary intake among Japanese individuals. Materials and Methods We randomly selected 898 (384 men and 514 women) participants aged 40–78 years in the Gifu Diabetes Study; those taking medication for dyslipidemia or diabetes mellitus were excluded. Serum levels of glucose metabolism parameters and the food frequency were measured cross‐sectionally. The glycated hemoglobin was measured again after 5 years. Results Glucose metabolism parameters and the percentage of individuals with impaired glucose tolerance were significantly higher in the high triglyceride group in men and women. Similar trends were observed in the low high‐density lipoprotein group, but only in men. Meanwhile, only the homeostasis model assessment of insulin resistance was higher in the high low‐density lipoprotein group. In non‐obese men, the percentage of energy intake from alcohol per total daily energy intake was significantly greater in the high triglyceride group. In obese women, the total energy intake was significantly greater in the high triglyceride group. At the 5‐year follow up, the risk of elevated glycated hemoglobin levels with hypertriglyceridemia was increased in men. Conclusions Hypertriglyceridemia is a stronger risk factor for impaired glucose tolerance than increased low‐density lipoprotein or decreased high‐density lipoprotein. For dietary habits, increased daily alcohol energy intake in non‐obese men and increased total energy intake in obese women were associated with hypertriglyceridemia.
Hypertriglyceridemia has a negative effect on glucose metabolism by increasing insulin resistance and secretion. Further, such effect was stronger than hyper‐LDL or lower‐HDL cholesterolemia in the Japanese with dyslipidemia‐induced impaired glucose tolerance. For dietary habits, increased daily alcohol energy intake in non‐obese men and increased total energy intake in obese women were associated with hypertriglyceridemia.
Databáze: OpenAIRE
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