The Pharmacological Effects and Pharmacokinetics of Active Compounds of Artemisia capillaris
| Autor: | Tung Hu Tsai, Tun Pin Hsueh, Wan Ling Lin, Jeffrey W. Dalley |
|---|---|
| Přispěvatelé: | Hsueh, Tun-Pin [0000-0002-0107-7961], Dalley, Jeffrey W [0000-0002-2282-3660], Tsai, Tung-Hu [0000-0002-9007-2547], Apollo - University of Cambridge Repository, Dalley, Jeffrey [0000-0002-2282-3660] |
| Rok vydání: | 2021 |
| Předmět: |
Cirrhosis
food.ingredient QH301-705.5 Medicine (miscellaneous) Review Artemisia General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Yin-Chen food Chlorogenic acid Pharmacokinetics Scopoletin Medicine Biology (General) scoparone biology Traditional medicine business.industry medicine.disease biology.organism_classification Scoparone chemistry Herb herbal medicine pharmacology business Viral hepatitis pharmacokinetics |
| Zdroj: | Biomedicines Biomedicines, Vol 9, Iss 1412, p 1412 (2021) |
| Popis: | Artemisia capillaris Thunb. (A.capillaris, Yin-Chen in Chinese) is a traditional medicinal herb with a wide spectrum of pharmacological properties ranging from effects against liver dysfunction to treatments of severe cirrhosis and cancer. We used relevant keywords to search electronic databases, including PubMed, Medline, and Google Scholar, for scientific contributions related to this medicinal herb and the pharmacokinetics of its components. The pharmaceutical effects of A.capillaris contribute to the treatment not only of viral hepatitis, cirrhosis, and hepatocellular hepatoma, but also metabolic syndrome, psoriasis, and enterovirus in the clinic. The bioactive compounds, including scoparone, capillarisin, scopoletin, and chlorogenic acid, exhibit antioxidant, anti-inflammatory, antisteatotic, antiviral, and antitumor properties, reflecting the pharmacological effects of A.capillaris. The pharmacokinetics of the main bioactive compounds in A. capillaris can achieve a maximum concentration within 1 hour, but only chlorogenic acid has a relatively long half-life. Regarding the use of the A. capillaris herb by health professionals to treat various diseases, the dosing schedule of this herb should be carefully considered to maximize therapeutic outcomes while lessening possible side effects. |
| Databáze: | OpenAIRE |
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