Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study
Autor: | Jing Si, Yan Zheng, Hongxia Zhao, Shalaimaiti Shali, Xin Dong, Yuxiang Dai, Junbo Ge, Daoyuan Ren, Shufu Chang, Lili Xu, Zhonghan Sun, Qianqian Tian, Zhengdong Mei |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Acute coronary syndrome Metabolite score Endocrinology Diabetes and Metabolism Metabolite Medicine (miscellaneous) Renal function Trimethylamine N-oxide lcsh:TX341-641 030204 cardiovascular system & hematology Gastroenterology Choline 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Intestinal flora Internal medicine medicine 030212 general & internal medicine lcsh:RC620-627 Nutrition and Dietetics business.industry Research Case-control study Odds ratio medicine.disease Cardiovascular risk lcsh:Nutritional diseases. Deficiency diseases chemistry business Body mass index lcsh:Nutrition. Foods and food supply |
Zdroj: | Nutrition & Metabolism Nutrition & Metabolism, Vol 17, Iss 1, Pp 1-9 (2020) |
ISSN: | 1743-7075 |
Popis: | Background Accumulating evidence shows that circulating levels of trimethylamine N-oxide, which is generated from the metabolism of dietary choline, may predict cardiovascular disease among Caucasians. Acute coronary syndrome (ACS), one common presentation of cardiovascular disease, is a spectrum of signs and symptoms due to acute decreased blood flow in the coronary arteries. The relationship between the metabolites from choline pathway and ACS remains unclear. We aimed to assess the associations of circulating metabolites from the choline pathway with ACS among a Chinese population, who consume a different dietary pattern than their Western counterparts. Methods We recruited 501 participants who were admitted to the Department of Cardiology, Zhongshan Hospital,Shanghai China between March 2017 and June 2018, including 254 ACS cases and 247 controls. Liquid chromatography-tandem mass spectrometry was used to measure circulating concentrations of metabolites in the choline pathway, including betaine, choline, trimethylamine, and trimethylamine N-oxide. A composite metabolite score using a weighted sum of these four metabolites, and the betaine/choline ratio were calculated. Multivariable logistic regressions were applied to estimate the association of metabolites with ACS, with adjustment of age, sex, body mass index, smoking index, history of diseases, and kidney function. Results After adjusting for traditional risk factors, per 1-standard deviation (SD) increment in choline was positively associated with the odds of ACS [odds ratio (OR), 95% confidence interval (CI), 1.77(1.44–2.18)], and the other metabolites were not associated with ACS at a statistical significance level. Compared with participants in the lowest quartile of the metabolite score, those in the highest quartile had higher odds of ACS [OR (95% CI), 3.18(1.85–5.54), p Conclusions Among our Chinese participants, trimethylamine N-oxide was not associated with ACS, while a composite metabolite score of metabolites from the choline pathway was associated with increased odds of ACS. The choline pathway metabolites may be related to the pathophysiology of ACS among Chinese. |
Databáze: | OpenAIRE |
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