Hypersensitivity reaction to pegylated liposomal doxorubicin administration for Mullerian carcinoma in Japanese women
| Autor: | Ichiro Onoyama, Kiyoko Kato, Masafumi Yasunaga, Keisuke Kodama, Hideaki Yahata, Tatsuhiro Ohgami, Hiroshi Yagi, Shinichiro Yamaguchi, Kaoru Okugawa, Kazuo Asanoma |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
PEGylated liposomal doxorubicin Gastroenterology Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dexamethasone Sodium Phosphate Japan Internal medicine hypersensitive reaction Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Adverse effect Retrospective Studies Ovarian Neoplasms 030219 obstetrics & reproductive medicine business.industry Incidence (epidemiology) Granisetron Hydrochloride Obstetrics and Gynecology medicine.disease Carboplatin Hypersensitivity reaction enzymes and coenzymes (carbohydrates) chemistry Doxorubicin 030220 oncology & carcinogenesis Female lipids (amino acids peptides and proteins) Premedication business |
| Zdroj: | Journal of Obstetrics and Gynaecology Research. 47:1544-1548 |
| ISSN: | 1447-0756 1341-8076 |
| DOI: | 10.1111/jog.14680 |
| Popis: | Aim / PEGylated liposomal doxorubicin (PLD) is a therapeutic agent for gynecological malignancy. Hypersensitivity reaction (HSR) is a major adverse effect that usually disappears after halting administration of PLD. Premedication is usually not necessary before administration of PLD to prevent HSR. Here, we evaluated the frequency of HSR during administration of PLD following premedication in Japanese women. / Methods / We performed PLD administration in 78 patients (386 cycles) between 2013 and 2018. Granisetron hydrochloride and dexamethasone sodium phosphate were administered 30 min before PLD administration. Then, PLD (40 or 30 mg/m2 combined usage with carboplatin) was administered. We retrospectively reviewed the medical records of 78 patients and examined the frequency of HSR. / Results / Seven of 78 (9%) patients showed HSR by PLD administration following premedication. One patient showed cardiopulmonary arrest in 13 min after PLD administration (grade 4). The other six patients showed grade 2 HSR. All patients developed HSR in the first course. The incidence of HSR was significantly higher in patients with allergic history than in patients without allergic history (p = 0.0151). / Conclusions / Clinicians should be aware of the potential for HSR in patients administered PLD, particularly those with allergic history and those receiving the first cycle of PLD, even following premedication. |
| Databáze: | OpenAIRE |
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