Extracellular Vesicles and Antiphospholipid Syndrome: State-of-the-Art and Future Challenges

Autor: Saša Čučnik, Ula Štok, Polona Žigon, S. Sodin-Semrl
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Blood Platelets
QH301-705.5
Review
030204 cardiovascular system & hematology
Extracellular vesicles
Catalysis
Monocytes
Preeclampsia
Proinflammatory cytokine
Inorganic Chemistry
preeclampsia
03 medical and health sciences
Extracellular Vesicles
0302 clinical medicine
Pre-Eclampsia
Antiphospholipid syndrome
Pregnancy
medicine
Humans
Platelet
placental explants
Physical and Theoretical Chemistry
Endothelial dysfunction
Biology (General)
Receptor
Molecular Biology
QD1-999
Spectroscopy
business.industry
Organic Chemistry
antiphospholipid antibodies
Endothelial Cells
Thrombosis
General Medicine
Plasma levels
medicine.disease
Antiphospholipid Syndrome
Computer Science Applications
Trophoblasts
Chemistry
030104 developmental biology
Immunology
platelets
Antibodies
Antiphospholipid
Female
business
Biomarkers
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 4689, p 4689 (2021)
ISSN: 1422-0067
Popis: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thromboembolism, obstetric complications, and the presence of antiphospholipid antibodies (aPL). Extracellular vesicles (EVs) play a key role in intercellular communication and connectivity and are known to be involved in endothelial and vascular pathologies. Despite well-characterized in vitro and in vivo models of APS pathology, the field of EVs remains largely unexplored. This review recapitulates recent findings on the role of EVs in APS, focusing on their contribution to endothelial dysfunction. Several studies have found that APS patients with a history of thrombotic events have increased levels of EVs, particularly of endothelial origin. In obstetric APS, research on plasma levels of EVs is limited, but it appears that levels of EVs are increased. In general, there is evidence that EVs activate endothelial cells, exhibit proinflammatory and procoagulant effects, interact directly with cell receptors, and transfer biological material. Future studies on EVs in APS may provide new insights into APS pathology and reveal their potential as biomarkers to identify patients at increased risk.
Databáze: OpenAIRE
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