Genetic variation in the human brain dopamine system influences motor learning and its modulation by L-Dopa
| Autor: | Daniel Acevedo, Steven C. Cramer, Kristin M. Pearson-Fuhrhop, Babak Shahbaba, Brian Minton |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_treatment Dopamine lcsh:Medicine Biochemistry Levodopa 0302 clinical medicine Learning and Memory Medicine and Health Sciences lcsh:Science Motor skill 0303 health sciences ANKK1 Multidisciplinary Neuronal Plasticity Dopaminergic Brain Neurochemistry medicine.anatomical_structure Motor Skills Medicine Female Neurochemicals Motor learning medicine.drug Motor cortex Research Article Adult medicine.medical_specialty Drugs and Devices Neuroimaging Biology Models Biological Polymorphism Single Nucleotide 03 medical and health sciences Young Adult medicine Genetics Humans Learning Psychiatry Genetic Association Studies 030304 developmental biology Motor Systems lcsh:R Genetic Variation Human Genetics Transcranial magnetic stimulation Pharmacogenetics lcsh:Q Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | PLoS ONE, Vol 8, Iss 4, p e61197 (2013) PLoS ONE Pearson-Fuhrhop, Kristin M.; Minton, Brian; Acevedo, Daniel; Shahbaba, Babak; & Cramer, Steven C.(2013). Genetic Variation in the Human Brain Dopamine System Influences Motor Learning and Its Modulation by L-Dopa. PLoS ONE, 8(4). UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/86p5279s |
| ISSN: | 1932-6203 |
| Popis: | Dopamine is important to learning and plasticity. Dopaminergic drugs are the focus of many therapies targeting the motor system, where high inter-individual differences in response are common. The current study examined the hypothesis that genetic variation in the dopamine system is associated with significant differences in motor learning, brain plasticity, and the effects of the dopamine precursor L-Dopa. Skilled motor learning and motor cortex plasticity were assessed using a randomized, double-blind, placebo-controlled, crossover design in 50 healthy adults during two study weeks, one with placebo and one with L-Dopa. The influence of five polymorphisms with established effects on dopamine neurotransmission was summed using a gene score, with higher scores corresponding to higher dopaminergic neurotransmission. Secondary hypotheses examined each polymorphism individually. While training on placebo, higher gene scores were associated with greater motor learning (p = .03). The effect of L-Dopa on learning varied with the gene score (gene score*drug interaction, p = .008): participants with lower gene scores, and thus lower endogenous dopaminergic neurotransmission, showed the largest learning improvement with L-Dopa relative to placebo (p |
| Databáze: | OpenAIRE |
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