The Role of Genetic Ancestry in Brazilian Patients With Primary Congenital Glaucoma
| Autor: | Sebastião Cronemberger, Luciana Bastos-Rodrigues, Hévila Rolim, Hayana Rangel, Luiz De Marco, Wagner D. Batista |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
Genetic Markers Male medicine.medical_specialty Genotype Genetic genealogy Population Glaucoma Black People Positive correlation White People 03 medical and health sciences Tonometry Ocular 0302 clinical medicine INDEL Mutation Internal medicine medicine Ethnicity Humans education Child Intraocular Pressure Prior Surgery education.field_of_study business.industry Primary congenital glaucoma Hydrophthalmos Infant Newborn Infant Mean age Axial length medicine.disease Ophthalmology 030104 developmental biology Genetics Population Filtering Surgery 030221 ophthalmology & optometry Female business Brazil |
| Zdroj: | Journal of glaucoma. 25(1) |
| ISSN: | 1536-481X |
| Popis: | PURPOSE The relationship between clinical data and genetic ancestry in Brazilian patients with primary congenital glaucoma (PCG) was studied. PATIENTS AND METHODS Thirty patients with PCG and 60 unrelated controls underwent a complete ophthalmological examination. The PCG inclusion criterion was prior surgery with a minimum follow-up of 6 months after the last surgical procedure. Clinical data were recorded and DNA from each individual was extracted and genotyped for a panel of 40 validated ancestry-informative insertion-deletion DNA polymorphisms (indels). RESULTS Eighteen (60%) children had bilateral disease and 16 (53.3%) were male. The mean age at diagnosis was 6.3 months and surgical follow-up time varied from 8 to 85 months. For the PCG group, the proportion of Europeans, Africans, and Amerindians was 0.784±0.044 (mean±SEM), 0.149±0.035, and 0.067±0.023, respectively, whereas for the control group was 0.730±0.048, 0.132±0.034, and 0.138±0.032, respectively. An increased proportion of African indels was associated with worse surgical prognosis (P=0.036). There was also a statistically significant (P |
| Databáze: | OpenAIRE |
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