Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplification

Autor:	Chang Liu, Yu-Jie Zhou, Xia Chu, Cunpeng Nie, Yuan-Hui Wan, Juan Zhang, Ke-Jing Xiao, Ting-Ting Chen
Rok vydání:	2019
Předmět:	Deoxyribozyme Color 010402 general chemistry 01 natural sciences Catalysis Neoplasm genetics Cell Line Tumor microRNA Materials Chemistry Humans RNA Neoplasm 010405 organic chemistry Chemistry Hydrolysis Metals and Alloys DNA Catalytic General Chemistry Highly selective 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials MicroRNAs Molecular Probes Ceramics and Composites Biophysics Self cleavage Nucleic Acid Amplification Techniques Signal amplification
Zdroj:	Chemical Communications. 55:3278-3281
ISSN:	1364-548X 1359-7345
Popis:	In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also be monitored.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3186073dd47c9333ac9da9f62671780 https://doi.org/10.1039/c9cc00451c Zobrazit plný text záznamu