Antivirals and vaccines for Enterovirus A71
| Autor: | Shin-Ru Shih, Jing Yi Lin, Yu-An Kung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Enterovirus A71 Clinical Biochemistry lcsh:Medicine Disease Review Herpangina Antiviral Agents Virus 03 medical and health sciences Mice 0302 clinical medicine medicine Enterovirus Infections Animals Humans Pharmacology (medical) Molecular Biology Vaccines Attenuated vaccine business.industry Biochemistry (medical) lcsh:R Viral Vaccines Cell Biology General Medicine Enterovirus a71 medicine.disease Antivirals Virology Enterovirus A Human 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-10 (2019) Journal of Biomedical Science |
| ISSN: | 1423-0127 |
| Popis: | Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children under five years old. EV-A71 infection in infants or young children can cause hand-foot-and-mouth disease, herpangina, or severe neurological complications. However, there are still no effective antivirals for treatment of these infections. In this review, we summarize the antiviral compounds developed to date based on various targets of the EV-A71 life cycle. Moreover, development of a vaccine would be the most effective approach to prevent EV-A71 infection. Therefore, we also summarize the development and clinical progress of various candidate EV-A71 vaccines, including inactivated whole virus, recombinant VP1 protein, synthetic peptides, viral-like particles, and live attenuated vaccines. |
| Databáze: | OpenAIRE |
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