Endothelin-1 Production by Normal Human Cultured Keratinocytes and its Regulation
| Autor: | Masaki Aihara, Hirotomo Ishida, N. Tane, Kazumasa Ando, Miwa Yamanaka, Nagaoki Wakisaka, Hajime Inoue, Emiko Isono |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
medicine.hormone
business.industry Immunology Interleukin Human skin Cell Biology Heparin Endothelin 1 Cell biology law.invention Endothelins Thrombin medicine.anatomical_structure law lcsh:Pathology Recombinant DNA cardiovascular system Medicine business Keratinocyte lcsh:RB1-214 medicine.drug Research Article |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 3, Iss 6, Pp 433-437 (1994) |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | The possibility that cultured keratinocytes produce endothelins were investigated. The results showed that cultured keratinocytes derived from normal human skin produce endothelin-1. Moreover, keratinocyte endothelin-1 production was completely inhibited by the presence of actinomycin D in the medium. As in the case of endothelial cells, recombinant interleukin-1β was capable of promoting endothelin-1 production in keratinocytes, whereas herapin inhibited it. Thrombin also inhibited endothelin-1 production. These results indicate that the mechanism of endothelin-1 production in keratinocytes is slightly different from the mechanism in vascular endothelial cells. |
| Databáze: | OpenAIRE |
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