Epidemiological Characteristics and Adverse Events of Patients with Psoriatic Arthritis Undergoing Treatment with Biological Therapies in Galicia
| Autor: | José A. Mosquera Martínez, María Noelia Álvarez Rivas, José Antonio Pinto Tasende, Luis Fernández Dominguez, Blanca Correa Rey, Carlos García Porrúa, Francisco J. Maceiras Pan, Loreto Carmona |
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| Rok vydání: | 2019 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty Latent tuberculosis business.industry General Medicine medicine.disease Etanercept 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Internal medicine Fibromyalgia Cohort Chemoprophylaxis Epidemiology medicine 030212 general & internal medicine Adverse effect business medicine.drug |
| Zdroj: | Reumatologia clinica. 17(3) |
| ISSN: | 2173-5743 |
| Popis: | Patients with severe forms of psoriatic arthritis (PsA) usually require treatment with biological agents. A greater knowledge of this subgroup of patients and their treatment enables better decision making in real clinical practice. Methods Longitudinal, multicentric observational study. We included all patients older than 16 years diagnosed with PsA in treatment with biological therapies from January 1, 2011 to December 31, 2015 treated in 6 Galician hospitals. Results Six hundred and four patients with PsA received biological therapies. Etanercept was the most used biological treatment. The average time of follow-up was 2.5 years and 67.9% were being treated with the first biological treatment. They were mostly patients with the peripheral subtype and met the criteria for clinical remission. Thirty-two percent had positive HLA-B27 and it was associated with axial PA subtypes. The prevalence of tuberculosis treated previously was 5.9%, and 23% of patients received chemoprophylaxis for latent tuberculosis. Twenty-four patients had undergone a prosthetic replacement. Hip prosthesis was the most frequent. Ninety-nine cases were treated for affective disorders. A diagnosis of fibromyalgia was established in 11 cases mostly women. Of the cases, 6.6% had episodes of serious infections, with respiratory infections being the most frequent. Sixteen tumours were detected (2.9%). Prostate cancer and gynaecological tumours were the most frequent. As with infections, the greater the age the greater the risk of presenting a tumour. Conclusions We describe the epidemiological and safety characteristics in real life of a Galician multicentre cohort of patients with psoriatic arthritis under biological treatment |
| Databáze: | OpenAIRE |
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