Acetazolamide reduces exercise capacity following a 5-day ascent to 4559 m in a randomised study
| Autor: | John Delamere, Carla A. Rue, Alex D. Wright, Stephen Harris, Arthur R. Bradwell, Kimberley Ashdown, Samuel J. E. Lucas, Owen Thomas, Stephen D. Myers |
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| Rok vydání: | 2018 |
| Předmět: |
Future studies
Physical Therapy Sports Therapy and Rehabilitation 030204 cardiovascular system & hematology Placebo RC1200 03 medical and health sciences 0302 clinical medicine Exercise performance Heart rate Medicine Orthopedics and Sports Medicine 030212 general & internal medicine GV557 elderly people exercise business.industry Effects of high altitude on humans Exercise capacity Anesthesia Original Article Bicycle ergometer business Acetazolamide altitude medicine.drug |
| Zdroj: | BMJ Open Sport — Exercise Medicine |
| ISSN: | 2055-7647 |
| DOI: | 10.1136/bmjsem-2017-000302 |
| Popis: | ObjectiveTo assess whether acetazolamide (Az), used prophylactically for acute mountain sickness (AMS), alters exercise capacity at high altitude.MethodsAz (500 mg daily) or placebo was administered to 20 healthy adults (aged 36±20 years, range 21–77), who were paired for age, sex, AMS susceptibility and weight, in a double-blind, randomised manner. Participants ascended over 5 days to 4559 m, then exercised to exhaustion on a bicycle ergometer, while recording breath-by-breath gas measurements. Comparisons between groups and matched pairs were done via Mann-Whitney U and Pearson’s χ2tests, respectively.ResultsComparing paired individuals at altitude, those on Az had greater reductions in maximum power output (Pmax) as a percentage of sea-level values (65±14.1 vs 76.6±7.4 (placebo); P=0.007), lower VO2max(20.7±5.2 vs 24.6±5.1 mL/kg/min; Pmaxfor VO2(9.8±6.2 vs 13.8±4.9 mL/kg/min; P=0.04) and lower heart rate at Pmax(154±25 vs 167±16, Pmax(r=−0.83: Pmax(r=−0.71, P=0.01) reduced more in those taking Az.ConclusionMaximum exercise performance at altitude was reduced more in subjects taking Az compared with placebo, particularly in older individuals. The age-related effect may reflect higher tissue concentrations of Az due to reduced renal excretion. Future studies should explore the effectiveness of smaller Az doses (eg, 250 mg daily or less) in older individuals to optimise the altitude–Az–exercise relationships. |
| Databáze: | OpenAIRE |
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