The discovery and structure–activity relationships leading to CE-156811, a difluorophenyl cyclopropyl fluoroether: A novel potent antibacterial analog derived from hygromycin A

Autor:	Steve Finegan, Jennifer L. Liras, John Schafer, Gregory G. Stone, Sarah K. Wade, Ann G. Connolly, Rhonda Monahan, Katherine E. Brighty, Joan Duignan, Steven J. Brickner, Phuong Le, Ivan J. Samardjiev, Richard P. Zaniewski, Dennis Girard, Jon Bordner, Meghan Maloney
Rok vydání:	2011
Předmět:	medicine.drug_class Stereochemistry Clinical Biochemistry Drug Evaluation Preclinical Administration Oral Pharmaceutical Science Carboxamide Ether Dioxoles Microbial Sensitivity Tests Biochemistry Chemical synthesis Mice Structure-Activity Relationship chemistry.chemical_compound Dogs Drug Discovery Ribose medicine Animals Molecular Biology Antibacterial agent Organic Chemistry Aminoglycoside Haplorhini Anti-Bacterial Agents Rats carbohydrates (lipids) chemistry Cinnamates Molecular Medicine Hygromycin B Hygromycin A
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 21:276-279
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2010.11.022
Popis:	SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4'-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the ribose ring and difluorination of the phenyl found in Hygromycin A, are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31058e211b4e5cd78b92b592ecef72f https://doi.org/10.1016/j.bmcl.2010.11.022 Zobrazit plný text záznamu Full Text from ScienceDirect