Quantitative and qualitative differences in subcutaneous adipose tissue stores across lipodystrophy types shown by magnetic resonance imaging
| Autor: | Robert A. Hegele, Cynthia Harper Little, Rhonda Walcarius, John F. Robinson, Salam A. Al-Attar, Rebecca L. Pollex, Brian K. Rutt, Brooke A Miskie |
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| Jazyk: | angličtina |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology lcsh:Medical technology Lipodystrophy Adipose tissue 030209 endocrinology & metabolism Thigh Bioimaging and Biomedical Optics Sensitivity and Specificity 030218 nuclear medicine & medical imaging Acquired Partial Lipodystrophy Congenital generalized lipodystrophy 03 medical and health sciences 0302 clinical medicine Computer-Assisted Internal medicine Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Image Interpretation medicine.diagnostic_test business.industry Partial Lipodystrophy Reproducibility of Results Magnetic resonance imaging Middle Aged Familial partial lipodystrophy medicine.disease Magnetic Resonance Imaging body regions medicine.anatomical_structure Endocrinology Adipose Tissue lcsh:R855-855.5 Medical Microbiology Radiology Nuclear Medicine and imaging Female business Medical Genetics Research Article |
| Zdroj: | BMC Medical Imaging, Vol 7, Iss 1, p 3 (2007) BMC Medical Imaging Robarts Vascular Research Publications |
| ISSN: | 1471-2342 |
| DOI: | 10.1186/1471-2342-7-3 |
| Popis: | Background Lipodystrophies are characterized by redistributed subcutaneous fat stores. We previously quantified subcutaneous fat by magnetic resonance imaging (MRI) in the legs of two patients with familial partial lipodystrophy subtypes 2 and 3 (FPLD2 and FPLD3, respectively). We now extend the MRI analysis across the whole body of patients with different forms of lipodystrophy. Methods We studied five subcutaneous fat stores (supraclavicular, abdominal, gluteal, thigh and calf) and the abdominal visceral fat stores in 10, 2, 1, 1 and 2 female subjects with, respectively, FPLD2, FPLD3, HIV-related partial lipodystrophy (HIVPL), acquired partial lipodystrophy (APL), congenital generalized lipodystrophy (CGL) and in six normal control subjects. Results Compared with normal controls, FPLD2 subjects had significantly increased supraclavicular fat, with decreased abdominal, gluteal, thigh and calf subcutaneous fat. FPLD3 subjects had increased supraclavicular and abdominal subcutaneous fat, with less severe reductions in gluteal, thigh and calf fat compared to FPLD2 subjects. The repartitioning of fat in the HIVPL subject closely resembled that of FPLD3 subjects. APL and CGL subjects had reduced upper body, gluteal and thigh subcutaneous fat; the APL subject had increased, while CGL subjects had decreased subcutaneous calf fat. Visceral fat was markedly increased in FPLD2 and APL subjects. Conclusion Semi-automated MRI-based adipose tissue quantification indicates differences between various lipodystrophy types in these studied clinical cases and is a potentially useful tool for extended quantitative phenomic analysis of genetic metabolic disorders. Further studies with a larger sample size are essential for confirming these preliminary findings. |
| Databáze: | OpenAIRE |
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