The association of urinary phosphorous-containing flame retardant metabolites and self-reported personal care and household product use among couples seeking fertility treatment

Autor: Craig M. Butt, Russ Hauser, Jennifer Ford, Heather M. Stapleton, Paige L. Williams, Courtney C. Carignan, Lidia Mínguez-Alarcón, Mary E. Ingle, John D. Meeker
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
Male
010504 meteorology & atmospheric sciences
Epidemiology
media_common.quotation_subject
Urinary system
Fertility
Urine
Cosmetics
010501 environmental sciences
Toxicology
01 natural sciences
Article
chemistry.chemical_compound
fluids and secretions
Plasticizers
Environmental health
Endocrine system
Medicine
Humans
Product (category theory)
0105 earth and related environmental sciences
General Environmental Science
media_common
Flame Retardants
Fertility Clinics
Personal care
business.industry
Biphenyl Compounds
Public Health
Environmental and Occupational Health
Household Products
Personal Care Product
Environmental Exposure
Pollution
humanities
Organophosphates
Nail polish
3. Good health
Biphenyl compound
chemistry
Massachusetts
DPHP
General Earth and Planetary Sciences
Female
Self Report
business
Fire retardant
Zdroj: Journal of Exposure Science & Environmental Epidemiology
ISSN: 1559-064X
1559-0631
Popis: Background Phosphorous-containing flame-retardants (PFRs) are widely detected. They are used both as a flame retardant as well as plasticizer. Methods A subset of 230 women and 229 men were recruited from Massachusetts General Hospital fertility clinic between 2005 and 2015. At each visit, participants completed a questionnaire of personal care product (PCP) and household product (HP) use. Metabolites [bis(1,3-dichloro-2-propyl) phosphate, diphenyl phosphate (DPHP), isopropylphenyl phenyl phosphate (ip-PPP), tert-butylphenyl phenyl phosphate and bis(1-chloro-2-propyl) phosphate] were measured in urine (1–5 samples; n = 638 women, n = 335 men). Associations were assessed using generalized mixed models, adjusted for SG, age, BMI, smoking, education, and season. Results In women, moisturizer (60%), nail polish remover (77%), and nail polish (134%) use were associated (p Conclusions Our exploratory analysis suggests PFRs may be used as a plasticizer in consumer products, and nail polish use contributes to internal DPHP exposure. Further research is needed to understand how PFRs are used in these products and how it relates to exposure.
Databáze: OpenAIRE
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