The association of urinary phosphorous-containing flame retardant metabolites and self-reported personal care and household product use among couples seeking fertility treatment
Autor: | Craig M. Butt, Russ Hauser, Jennifer Ford, Heather M. Stapleton, Paige L. Williams, Courtney C. Carignan, Lidia Mínguez-Alarcón, Mary E. Ingle, John D. Meeker |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Adult
Male 010504 meteorology & atmospheric sciences Epidemiology media_common.quotation_subject Urinary system Fertility Urine Cosmetics 010501 environmental sciences Toxicology 01 natural sciences Article chemistry.chemical_compound fluids and secretions Plasticizers Environmental health Endocrine system Medicine Humans Product (category theory) 0105 earth and related environmental sciences General Environmental Science media_common Flame Retardants Fertility Clinics Personal care business.industry Biphenyl Compounds Public Health Environmental and Occupational Health Household Products Personal Care Product Environmental Exposure Pollution humanities Organophosphates Nail polish 3. Good health Biphenyl compound chemistry Massachusetts DPHP General Earth and Planetary Sciences Female Self Report business Fire retardant |
Zdroj: | Journal of Exposure Science & Environmental Epidemiology |
ISSN: | 1559-064X 1559-0631 |
Popis: | Background Phosphorous-containing flame-retardants (PFRs) are widely detected. They are used both as a flame retardant as well as plasticizer. Methods A subset of 230 women and 229 men were recruited from Massachusetts General Hospital fertility clinic between 2005 and 2015. At each visit, participants completed a questionnaire of personal care product (PCP) and household product (HP) use. Metabolites [bis(1,3-dichloro-2-propyl) phosphate, diphenyl phosphate (DPHP), isopropylphenyl phenyl phosphate (ip-PPP), tert-butylphenyl phenyl phosphate and bis(1-chloro-2-propyl) phosphate] were measured in urine (1–5 samples; n = 638 women, n = 335 men). Associations were assessed using generalized mixed models, adjusted for SG, age, BMI, smoking, education, and season. Results In women, moisturizer (60%), nail polish remover (77%), and nail polish (134%) use were associated (p Conclusions Our exploratory analysis suggests PFRs may be used as a plasticizer in consumer products, and nail polish use contributes to internal DPHP exposure. Further research is needed to understand how PFRs are used in these products and how it relates to exposure. |
Databáze: | OpenAIRE |
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