Isobolographic Analysis of Pharmacodynamic Interactions between Antifungal Agents and Ciprofloxacin against Candida albicans and Aspergillus fumigatus
| Autor: | Paraskevi Papaioannidou, Joseph Meletiadis, Tin Sein, Thomas J. Walsh, Emmanuel Roilides, Ioannis Tsiouris, Theodouli Stergiopoulou |
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| Rok vydání: | 2008 |
| Předmět: |
Antifungal Agents
Microbial Sensitivity Tests Pharmacology Microbiology Aspergillus fumigatus chemistry.chemical_compound Ciprofloxacin Amphotericin B Candida albicans medicine Humans Drug Interactions Pharmacology (medical) Antibacterial agent Voriconazole Dose-Response Relationship Drug biology Drug Synergism biology.organism_classification Corpus albicans Anti-Bacterial Agents Infectious Diseases chemistry Susceptibility Regression Analysis Caspofungin Drug Antagonism medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 52:2196-2204 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00735-07 |
| Popis: | Patients suffering from invasive mycoses often receive concomitant antifungal therapy and antibacterial agents. Assessment of pharmacodynamic interactions between antifungal and antibacterial agents is complicated by the absence of a common antifungal end point for both agents. Ciprofloxacin has no intrinsic antifungal activity but may interact with antifungal agents, since it inhibits DNA gyrase (topoisomerase II), which is abundant in fungi. We therefore employed isobolographic analysis adapted to incorporate a nonactive agent in order to analyze the potential in vitro interaction between the fluoroquinolone ciprofloxacin and several representative antifungal agents against Candida albicans and Aspergillus fumigatus strains by using a microdilution checkerboard technique. In agreement with earlier in vitro studies, conventional fractional inhibitory concentration index analysis was unable to detect interactions between ciprofloxacin and antifungal agents. However, isobolographic analysis revealed significant pharmacodynamic interactions between antifungal agents and ciprofloxacin against C. albicans and A. fumigatus strains. Amphotericin B demonstrated concentration-dependent interactions for both species, with synergy (interaction indices, 0.14 to 0.81) observed at ciprofloxacin concentrations of A. fumigatus . Isobolographic analysis may help to elucidate the pharmacodynamic interactions between antifungal and non-antifungal agents and to develop better management strategies against invasive candidiasis and aspergillosis. |
| Databáze: | OpenAIRE |
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