Gout: An old disease in new perspective – A review
Autor: | Mohsen Elshahaly, Gaafar Ragab, Thomas Bardin |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
Gout Imaging modalities Arthritis Review Disease Hyperuricemia Pathogenesis Asymptomatic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Genetic predisposition Medicine Clinical picture of gout 030212 general & internal medicine lcsh:Science (General) Management of gout ComputingMethodologies_COMPUTERGRAPHICS 030203 arthritis & rheumatology lcsh:R5-920 Multidisciplinary medicine.diagnostic_test business.industry nutritional and metabolic diseases Magnetic resonance imaging medicine.disease chemistry Uric acid Radiology medicine.symptom business lcsh:Medicine (General) lcsh:Q1-390 |
Zdroj: | Journal of Advanced Research, Vol 8, Iss 5, Pp 495-511 (2017) Journal of Advanced Research |
ISSN: | 2090-1224 2090-1232 |
Popis: | Graphical abstract Gout is a picturesque presentation of uric acid disturbance. It is the most well understood and described type of arthritis. Its epidemiology is studied. New insights into the pathophysiology of hyperuricemia and gouty arthritis; acute and chronic allow for an even better understanding of the disease. The role of genetic predisposition is becoming more evident. The clinical picture of gout is divided into asymptomatic hyperuricemia, acute gouty arthritis, intercritical period, and chronic tophaceous gout. Diagnosis is based on laboratory and radiological features. The gold standard of diagnosis is identification of characteristic MSU crystals in the synovial fluid using polarized light microscopy. Imaging modalities include conventional radiography, ultrasonography, conventional CT, Dual-Energy CT, Magnetic Resonance Imaging, nuclear scintigraphy, and positron emission tomography. There is remarkable progress in the application of ultrasonography and Dual-Energy CT which is bound to influence the diagnosis, staging, follow-up, and clinical research in the field. Management of gout includes management of flares, chronic gout and prevention of flares, as well as management of comorbidities. Newer drugs in the pharmacological armamentarium are proving successful and supplement older ones. Other important points in its management include patient education, diet and life style changes, as well as cessation of hyperuricemic drugs. |
Databáze: | OpenAIRE |
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